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Publications

2020

Schäfer K.-H., Christmann A., Gries M. Can we trust the gut? The role of the intenstine in neurodegeneration. The Journal of Physiology. 2020 July 24. dx.doi.org/10.1113/JP280336.

 

Manuela Gries, Anne Christmann, Steven Schulte, Maximilian Weyland, Stephanie Rommel, Monika Martin, Marko Baller, Ralph Röth, Stefanie Schmitteckert, Marcus Unger, Yang Liu, Frederik Sommer, Timo Mühlhaus, Michael Schroda, Jean-Pierre Timmermans, Isabel Pintelon, Gudrun Rappold, Markus Britschgi, Hilal Lashuel, Michael D. Menger, Matthias W. Laschke, Beate Niesler, Karl-Herbert Schäfer. Functional and molecular early enteric biomarkers for Parkinson’s disease in mice and men. prepublished in bioarxive doi: doi.org/10.1101/2020.06.06.136556

 

Nguyen V. T. T. & Endres K. A crate of Pandora: do amyloids from bacteria promote Alzheimer’s disease? Neural Reg Res 2020

 

Schnöder L, Gasparoni G, Nordström K, Schottek A, Tomic I, Christmann A, Schäfer KH, Menger MD, Walter J, Fassbender K, Liu Y. Neuronal deficiency of p38α-MAPK ameliorates symptoms and pathology of APP or Tau-transgenic Alzheimer's mouse models. FASEB J. 2020 May 31. doi: 10.1096/fj.201902731RR. Online ahead of print.PMID: 32475008

 

dos Santos Guilherme M., Todorov H., Osterhof C., Möllerke A. , Cub K., Hankeln T., Gerber S. and Endres K. Impact of cute and Chronic Amyloid-β Peptide Exposure on Gut Microbial Commensals in the Mouse. Front. Microbiol., 20 May 2020 doi.org/10.3389/fmicb.2020.01008.

 

Under review: 15.03.20: Marz, SA., Jan A. Kullmann, JA, Mattson S. O. Jones, MSO., Fecher-Trost, C., Eggert, S., Jung, M., Alexander, RT., & Friauf. E., Interactome of Glycine transporter 2: CAPS1 regulates GlyT2 activity by promoting endocytosis. J Biol Chem

 

Delport A, Kins S, Hewer R. The amyloid precursor protein affects glyceraldehyde 3-phosphate dehydrogenase levels, organelle localisation and thermal stability. Mol Biol Rep. 2020 Apr;47(4):3019-3024. doi: 10.1007/s11033-020-05364-z. Epub 2020 Mar 9. PMID: 32152789.

 

Eggert S, Gruebl T, Rajender R, Rupp C, Sander B, Heesch A, Zimmermann M, Hoepfner S, Zentgraf H, Kins S. The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif. Cell Mol Life Sci. 2020 Feb 17. doi: 10.1007/s00018-020-03467-1. Epub ahead of print. PMID: 32065241.

 

Endres K. Amyloidogenic Peptides in Human Neuro-Degenerative Diseases and in Microorganisms: A Sorrow Shared Is a Sorrow Halved? Molecules 2020, 25, 925; doi:10.3390/molecules25040925

 

Gadomsky L, Santos Guilherme MD, Winkler J, der Kooij MV, Hartmann T, Grimm M, Endres K. Elevated Testosterone Level and Urine Scent Marking in Male 5xFAD Alzheimer Model Mice. Curr Alzheimer Res. 2020 Feb 16. doi: 10.2174/1567205017666200217105537.

 

Kiss E, Groeneweg F, Gorgas K, Schlicksupp A, Kins S, Kirsch J, Kuhse J. Amyloid-β Fosters p35/CDK5 Signaling Contributing to Changes of Inhibitory Synapses in Early Stages of Cerebral Amyloidosis. J Alzheimers Dis. 2020;74(4):1167-1187. doi: 10.3233/JAD-190976. PMID: 32144981.

 

Stoye N.M., dos Santos Guilherme M., Endres K. Alzheimer’s disease in the gut – major changes in the gut of 5xFAD model mice with ApoA1 as potential key player. FASEB J 2020 (angenommenes Manuskript).

 

Wagener K., Bros M., Krumb M., Langhanki J., Pektor S., Worm M., Schinnerer M., Montermann E., Miederer M., Frey H., Opatz T., Rösch F. (2020) Targeting of Immune Cells with Trimannosylated Liposomes, Advanced Therapeutics, 1900185.

 

F. Daus, E. Pfeifer, K. Seipp, N. A. Hampp, A. Geyer, The role of phosphopeptides in the mineralisation of silica, Organic & Biomolecular Chemistry, 2020, 18, 700 – 706.

 

2019

August A, Schmidt N, Klingler J, Baumkötter F, Lechner M, Klement J, Eggert S, Vargas C, Wild K, Keller S, Kins S. Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways. J Neurochem. 2019 Dec;151(5):626-641. doi: 10.1111/jnc.14716 . Epub 2019 Jun 6. PMID: 31063592 .

Weis S, Schwiertz A, Unger MM, Becker A, Faßbender K, Ratering S, Kohl M, Schnell S, Schäfer KH, Egert M. Effect of Parkinson's disease and related medications on the composition of the fecal bacterial microbiota. NPJ Parkinsons Dis. 2019 Nov 29;5:28. doi: 10.1038/s41531-019-0100-x . eCollection 2019.PMID: 31815177 Free PMC article.

Woelfer M, Li M, Colic L, Liebe T, Di X, Biswal B, Murrough J, Lessmann V, Brigadski T, Walter M. Ketamine-induced changes in plasma brain-derived neurotrophic factor (BDNF) levels are associated with the resting-state functional connectivity of the prefrontal cortex. World J Biol Psychiatry. 2019 Nov 4:1-15.

Wiesenborn DS, Gálvez EJC, Spinel L, Victoria B, Allen B, Schneider A, Gesing A, Al-Regaiey KA, Strowig T, Schäfer KH, Masternak MM. The role of Ames dwarfism and calorie restriction on gut microbiota. J Gerontol A Biol Sci Med Sci. 2019 Oct 30:glz236. doi: 10.1093/gerona/glz236. Online ahead of print.PMID: 31665244

Leschik J, Eckenstaler R, Endres T, Munsch T, Edelmann E, Richter K, Kobler O, Fischer KD, Zuschratter W, Brigadski T, Lutz B, Lessmann V. Prominent Postsynaptic and Dendritic Exocytosis of Endogenous BDNF Vesicles in BDNF-GFP Knock-in Mice. Mol Neurobiol. 2019 Oct;56(10):6833-6855.

Konietzko U, Gersbacher MT, Streuli J, Krüger M, Thöni S, Kins S, Nitsch RM. A fluorescent protein-readout for transcriptional activity reveals regulation of APP nuclear signaling by phosphorylation sites. Biol Chem. 2019 Aug 27;400(9):1191-1203. doi: 10.1515/hsz-2019-0125 . PMID: 31120852 .

Grundmann D, Loris E, Maas-Omlor S, Schäfer KH. Enteric Neurogenesis During Life Span Under Physiological and Pathophysiological Conditions. Anat Rec (Hoboken). 2019 Aug;302(8):1345-1353. doi: 10.1002/ar.24124

Hermey G, Hoffmeister-Ullerich SA, Merz B, Groß D, Kuhl D, Kins S. Amyloidosis causes downregulation of SorLA, SorCS1 and SorCS3 expression in mice. Biol Chem. 2019 Aug 27;400(9):1181-1189. doi: 10.1515/hsz-2019-0146 . PMID: 31095505 .

Brand B, Stoye NM, Guilherme MDS, Nguyen VTT, Baumgaertner JC, Schüffler A, Thines E, Endres K. Identification of Patulin from Penicillium coprobium as a Toxin for Enteric Neurons. Molecules. 2019 Jul 30;24(15). pii: E2776. doi: 10.3390/molecules24152776 .

Dos Santos Guilherme M, Stoye NM, Rose-John S, Garbers C, Fellgiebel A, Endres K. The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients. Front Aging Neurosci. 2019 Jul 23;11:182. doi:10.3389/fnagi.2019.00182 .

Manzine PR, Ettcheto M, Cano A, Busquets O, Marcello E, Pelucchi S, Di Luca M, Endres K, Olloquequi J, Camins A, Cominetti MR. ADAM10 in Alzheimer's disease: Pharmacological modulation by natural compounds and its role as a peripheral marker. Biomed Pharmacother. 2019 May;113:108661. doi: 10.1016/j.biopha.2019.108661 .

Hewel C, Kaiser J, Wierczeiko A, Linke J, Reinhardt C, Endres K, Gerber S. Common miRNA Patterns of Alzheimer's ase and Parkinson's Disease and Their Putative Impact on Commensal Gut Microbiota. Front Neurosci. 2019 Mar 5;13:113. doi: 10.3389/fnins.2019.00113 .

Reinhardt S, Schuck F, Stoye N, Hartmann T, Grimm MOW, Pflugfelder G, Endres K. Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease. Cell Mol Life Sci. 2019 Mar;76(5):1005-1025. doi: 10.1007/s00018-018-2998-2 .

Hollnagel JO, Elzoheiry S, Gorgas K, Kins S, Beretta CA, Kirsch J, Kuhse J, Kann O, Kiss E. Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer's disease amyloidosis. PLoS One. 2019 Jan 15;14(1):e0209228. doi: 10.1371/journal.pone.0209228 . PMID: 30645585 ; PMCID: PMC6333398.

Endres K. Retinoic Acid and the Gut Microbiota in Alzheimer's Disease: Fighting Back-to-Back? Curr Alzheimer Res. 2019;16(5):405-417. doi:10.2174/1567205016666190321163705 . PubMed PMID: 30907321 .

Kühlborn J, Konhäuser M, Groß J, Wich P, Opatz T (2019) Xylochemical Synthesis of Cytotoxic 2-Aminophenoxazinone-Type Natural Products Through Oxidative Cross Coupling, ACS Sustainable Chemistry and Engineering 7, 4414–4419.

2018

Becke A, Müller P, Dordevic M, Lessmann V, Brigadski T, Müller NG. Daily Intermittent Normobaric Hypoxia Over 2 Weeks Reduces BDNF Plasma Levels in Young Adults - A Randomized Controlled Feasibility Study. Front Physiol. 2018 Oct 1;9:1337.

Eggert S, Thomas C, Kins S, Hermey G. Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin. Mol Neurobiol. 2018 Jul;55(7):5809-5829. doi: 10.1007/s12035-017-0806-x. Epub 2017 Oct 27. PMID: 29079999.

Rehfeld K, Lüders A, Hökelmann A, Lessmann V, Kaufmann J, Brigadski T, Müller P, Müller NG. Dance training is superior to repetitive physical exercise in inducing brain plasticity in the elderly. PLoS One. 2018 Jul 11;13(7):e0196636.

Schäfer KH.Influence of Commensal Microbiota on the Enteric Nervous System and Its Role in Neurodegenerative Diseases. J Innate Immun. 2018 May 9:1-9. doi: 10.1159/000488629. [Epub ahead of print]

Schwiertz A, Spiegel J, Dillmann U, Grundmann D, Bürmann J, Faßbender K, Schäfer KH, Unger MM.Fecal markers of intestinal inflammation and intestinal permeability are elevated in Parkinson's disease. Parkinsonism Relat Disord. 2018 May;50:104-107. doi: 10.1016/j.parkreldis.2018.02.022.

Jordan W, Dobrowolny H, Bahn S, Bernstein HG, Brigadski T, Frodl T, Isermann B, Lessmann V, Pilz J, Rodenbeck A, Schiltz K, Schwedhelm E, Tumani H, Wiltfang J, Guest PC, Steiner J. Oxidative stress in drug-naïve first episode patients with schizophrenia and major depression: effects of disease acuity and potential confounders. Eur Arch Psychiatry Clin Neurosci. 2018 Mar;268(2):129-143.

Endres K, Schäfer KH. Influence of Commensal Microbiota on the Enteric Nervous System and Its Role in Neurodegenerative Diseases. J Innate Immun. 2018;10(3):172-180. doi:10.1159/000488629.

Kauhl U, Andernach L, Opatz T (2018) Total Synthesis of epi-Trichosetin, Journal of Organic Chemistry 83, 15170–15177.

Lipp A, Ferenc D, Gütz C, Geffe M, Vierengel N, Schollmeyer D, Schäfer HJ, Waldvogel SR, Opatz T (2018), A Regio- and Diastereoselective Anodic Aryl-Aryl-Coupling in the Biomimetic Total Synthesis of (–)-Thebaine, Angewandte Chemie International Edition 57, 11055-11059.

Nauth A. M., Konrad T., Papadopulu Z., Vierengel N., Lipp B., Opatz T., (2018) Synthesis of α-Aminonitriles using Aliphatic Nitriles, α-Amino Acids, and Hexacyanoferrate as Universally Applicable Non-Toxic Cyanide Sources, Green Chem., 20, 4217-4223.

Eggert S, Gonzalez AC, Thomas C, Schilling S, Schwarz SM, Tischer C, Adam V, Strecker P, Schmidt V, Willnow TE, Hermey G, Pietrzik CU, Koo EH, Kins S. Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. Cell Mol Life Sci. 2018 Jan;75(2):301-322. doi: 10.1007/s00018-017-2625-7. Epub 2017 Aug 10. PMID: 28799085.

Rudolph K, Walter, T, Erkel G. The fungal metabolite cyclonerodiol inhibits IL-4/IL-13 induced Stat6-signaling through blocking the association of Stat6 with p38, ERK1/2 and p300. Int. Immunopharmacol. 2018, 65: 392-401.

2017

Schreiber D, Marx L, Felix S, Clasohm J, Weyland M, Schäfer M, Klotz M, Lilischkis R, Erkel G, Schäfer KH.Anti-inflammatory Effects of Fungal Metabolites in Mouse Intestine as Revealed by In vitroModels. Front Physiol. 2017 Aug 7;8:566. doi: 10.3389/fphys.2017.00566. eCollection 2017.

Feilen LP, Haubrich K, Strecker P, Probst S, Eggert S, Stier G, Sinning I, Konietzko U, Kins S, Simon B, Wild K. Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction. Front Mol Neurosci. 2017 May 11;10:140. doi: 10.3389/fnmol.2017.00140. PMID: 28553201; PMCID: PMC5425604. eCollection 2017.

Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC, Kins S, Eggert S. APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission. J Neurosci. 2017 May 24;37(21):5345-5365. doi: 10.1523/JNEUROSCI.1875-16.2017. Epub 2017 Apr 27. PMID: 28450540; PMCID: PMC6596463.

Herr UM, Strecker P, Storck SE, Thomas C, Rabiej V, Junker A, Schilling S, Schmidt N, Dowds CM, Eggert S, Pietrzik CU, Kins S. LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State. Front Mol Neurosci. 2017 Apr 27;10:118. doi: 10.3389/fnmol.2017.00118. PMID: 28496400; PMCID: PMC5406469.eCollection 2017.

Müller P, Rehfeld K, Schmicker M, Hökelmann A, Dordevic M, Lessmann V, Brigadski T, Kaufmann J, Müller NG. Evolution of Neuroplasticity in Response to Physical Activity in Old Age: The Case for Dancing. Front Aging Neurosci. 2017 Mar 14;9:56.

Guénette S, Strecker P, Kins S. APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins. Front Mol Neurosci. 2017 Mar 30;10:87. doi: 10.3389/fnmol.2017.00087. PMID: 28424586; PMCID: PMC5371672.

Wild K, August A, Pietrzik CU, Kins S. Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments. Front Mol Neurosci. 2017 Jan 31;10:21. doi: 10.3389/fnmol.2017.00021. PMID: 28197076; PMCID: PMC5281630.

Bode C, Richter F, Spröte C, Brigadski T, Bauer A, Fietz S, Fritschy JM, Richter A. Altered postnatal maturation of striatal GABAergic interneurons in a phenotypic animal model of dystonia. Exp Neurol. 2017 Jan;287(Pt 1):44-53.

Reinhardt S, Stoye N, Luderer M, Kiefer F, Schmitt U, Lieb K, Endres K. Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks. Sci Rep. 2018 Jan 22;8(1):1329. doi: 10.1038/s41598-018-19577-7.

Brandscheid C, Schuck F, Reinhardt S, Schäfer KH, Pietrzik CU, Grimm M, Hartmann T, Schwiertz A, Endres K. Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model. J Alzheimers Dis. 2017;56(2):775-788. doi: 10.3233/JAD-160926.

Otto N, Ferenc D, Opatz T (2017), A Modular Access to (+/-)-Tubocurine and (+/-)-Curine - Formal Total Synthesis of Tubocurarine, Journal of Organic Chemistry 82, 1205–1217

Lakatos M. & Strieht D. (2017) Terrestrial Microalgae - Novel Concepts For Biotechnology And Applications , In: Canovas FM., Lüttge U. & Matyssek R. (Hrsg.) Progress in Botany, Springer, Vol. 79: 269-312

Strieth D., Schwing J., Kuhn S., Lakatos M., Muffler K. & Ulber R. (2017) A semi-continuous process based on an ePBR for the production of EPS using Trichocoleus sociatus. Journal of Biotechnology 256: 6-12

Rohr M, Oleinikov K, Jung M, Sandjo LP, Opatz T, Erkel G. Anti-inflammatory tetraquinane diterpenoids from a Crinipellis species. Bioorg Med Chem 2017; 25: 514-522.

2016

Meineck M, Schuck F, Abdelfatah S, Efferth T, Endres K. Identification of Phlogacantholide C as a Novel ADAM10 Enhancer from Traditional Chinese Medicinal Plants. Medicines (Basel). 2016 Dec 5;3(4). pii: E30. doi: 10.3390/medicines3040030.

Kundu A, Milosch N, Antonietti P, Baumkötter F, Zymny A, Müller UC, Kins S, Hajieva P, Behl C, Kögel D. Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP. Mol Neurobiol. 2016 Nov;53(9):5985-5994. doi: 10.1007/s12035-015-9501-y. Epub 2015 Nov 2. PMID: 26526841.

Grimm MO, Regner L, Mett J, Stahlmann CP, Schorr P, Nelke C, Streidenberger O, Stoetzel H, Winkler J, Zaidan SR, Thiel A, Endres K, Grimm HS, Volmer DA, Hartmann T. Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's Disease. Int J Mol Sci. 2016 Oct 29;17(11).

Unger MM, Spiegel J, Dillmann KU, Grundmann D, Philippeit H, Bürmann J, Faßbender K, Schwiertz A, Schäfer KH. Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls. Parkinsonism Relat Disord. 2016 Aug 26. pii: S1353-8020(16)30323-6. doi: 10.1016/j.parkreldis.2016.08.019. [Epub ahead of print] PMID: 27591074

Kiss E, Gorgas K, Schlicksupp A, Groß D, Kins S, Kirsch J, Kuhse J. Biphasic Alteration of the Inhibitory Synapse Scaffold Protein Gephyrin in Early and Late Stages of an Alzheimer Disease Model. Am J Pathol. 2016 Sep;186(9):2279-91. doi: 10.1016/j.ajpath.2016.05.013. Epub 2016 Jul 14. PMID: 27423698.

Morfini G, Schmidt N, Weissmann C, Pigino G, Kins S. Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease. Brain Res Bull. 2016 Sep;126(Pt 3):347-353. doi: 10.1016/j.brainresbull.2016.06.009. Epub 2016 Jun 20. PMID: 27339812.

Strecker P, Ludewig S, Rust M, Mundinger TA, Görlich A, Krächan EG, Mehrfeld C, Herz J, Korte M, Guénette SY, Kins S. FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation. Sci Rep. 2016 May 11;6:25652. doi: 10.1038/srep25652. PMID: 27734846; PMCID: PMC4899880.

Tauber J, Rohr M, Walter T, Schollmeyer D, Rahn-Hotze K, Erkel G, Opatz T (2016) A Surprising Switch in Absolute Configuration of Anti-Inflammatory Macrolactones. Organic and Biomolecular Chemistry 14, 3695-3698.

Schega L, Peter B, Brigadski T, Lessmann L, Isermann B, Hamacher D, Törpel A (2016). Effect of intermittent normobaric hypoxia on physical performance and cognitive function in older people. J Sci Med Sport. S1440-2440(16)00063-3.

Eckenstaler R, Lessmann V, Brigadski T (2016). CAPS1 critically regulates BDNF release and intragranular pH of secretory granules. J Cell Sci. 129(7):1378-90.

Seifert B, Eckenstaler R, Rönicke R, Leschik J, Lutz B, Reymann K, Lessmann V, Brigadski T (2016) Amyloid-beta-induced changes in vesicular transport of BDNF in hippocampal neurons. Neural Plast. 2016:4145708.

2015

Hermey G, Schmidt N, Bluhm B, Mensching D, Ostermann K, Rupp C, Kuhl D, Kins S. SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport. J Neurochem. 2015 Oct;135(1):60-75. doi: 10.1111/jnc.13221. Epub 2015 Aug 26. PMID: 26119586.

Isolation of high-purity myenteric plexus from adult human and mouse gastrointestinal tract. Grundmann D, Klotz M, Rabe H, Glanemann M, Schäfer KH. Sci Rep. 2015 Mar 20;5:9226. doi: 10.1038/srep09226.

Renziehausen J, Hiebel C, Nagel H, Kundu A, Kins S, Kögel D, Behl C, Hajieva P. The cleavage product of amyloid-β protein precursor sAβPPα modulates BAG3-dependent aggresome formation and enhances cellular proteasomal activity. J Alzheimers Dis. 2015;44(3):879-96. doi: 10.3233/JAD-140600. PMID: 25362034.

Tauber J, Rohr M, Walter T, Erkel G, Opatz T (2015) Total Synthesis of two Potent Anti Inflammatory Macrolactones of the Oxacyclododecindione Type. Organic and Biomolecular Chemistry 13, 7813-7821.

Tauber J, Rudolph K, Rohr M, Erkel G, Opatz T (2015) Synthetic Approaches to Anti-Inflammatory Macrolactones of the Oxacyclododecindione Type. European Journal of Organic Chemistry, 3587-3608.

Richter J, Sandjo L P, Liermann J C, Opatz T, Erkel G (2015) 4-Dechloro-14-deoxy-oxacyclododecindione and 14-Deoxy-oxacylododecindione, two Inhibitors of Inducible Connective Tissue Growth Factor Expression from the Imperfect Fungus Exserohilum rostratum. Bioorganic & Medicinal Chemistry, 23, 556-563.

Maass A, Duzel S, Brigadski T, Goerke M, Becke A, Sobieray U, Neumann K, Lovden M, Lindenberger U, Backman L, Braun-Dullaeus R, Ahrens D, Heinze HJ, Muller NG, Lessmann V, Sendtner M, and Duzel E. (2015). Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults. Neuroimage. 131:142-54.

Edelmann E, Franck M, Lichtenecker P, Brigadski T, Leßmann V. (2015) Theta burst firing recruits BDNF release and signaling in postsynaptic CA1 neurons in spike timing-dependent LTP. Neuron 86(4):1041-54.

2014

Stahl R, Schilling S, Soba P, Rupp C, Hartmann T, Wagner K, Merdes G, Eggert S, Kins S. Shedding of APP limits its synaptogenic activity and cell adhesion properties. Front Cell Neurosci. 2014 Dec 3;8:410. doi: 10.3389/fncel.2014.00410. PMID: 25520622; PMCID: PMC4253958.

Rupp C, Beyreuther K, Maurer K, Kins S. A presenilin 1 mutation in the first case of Alzheimer's disease: revisited. Alzheimers Dement. 2014 Nov;10(6):869-72. doi: 10.1016/j.jalz.2014.06.005. Epub 2014 Aug 15. PMID: 25130656.

Milosch N, Tanriöver G, Kundu A, Rami A, François JC, Baumkötter F, Weyer SW, Samanta A, Jäschke A, Brod F, Buchholz CJ, Kins S, Behl C, Müller UC, Kögel D. Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway. Cell Death Dis. 2014 Aug 28;5(8):e1391. doi: 10.1038/cddis.2014.352. PMID: 25165877; PMCID: PMC4454324.

Baumkötter F, Schmidt N, Vargas C, Schilling S, Weber R, Wagner K, Fiedler S, Klug W, Radzimanowski J, Nickolaus S, Keller S, Eggert S, Wild K, Kins S. Amyloid precursor protein dimerization and synaptogenic function depend on copper binding to the growth factor-like domain. J Neurosci. 2014 Aug 13;34(33):11159-72. doi: 10.1523/JNEUROSCI.0180-14.2014. PMID: 25122912; PMCID: PMC6705248.

Klevanski M, Saar M, Baumkötter F, Weyer SW, Kins S, Müller UC. Differential role of APP and APLPs for neuromuscular synaptic morphology and function. Mol Cell Neurosci. 2014 Jul;61:201-10. doi: 10.1016/j.mcn.2014.06.004. Epub 2014 Jul 4. PMID: 24998676.

Koppenhöfer D, Kettenbaum F, Susloparova A, Law JK, Vu XT, Schwab T, Schäfer KH, Ingebrandt S. Neurodegeneration through oxidative stress: Monitoring hydrogen peroxide induced apoptosis in primary cells from the subventricular zone of BALB/c mice using field-effect transistors. Biosens Bioelectron. 2015 May 15;67:490-6. doi: 10.1016/j.bios.2014.09.012.

Schuster A, Klotz M, Schwab T, Di Liddo R, Bertalot T, Schrenk S, Martin M, Nguyen TD, Nguyen TNQ, Gries M, Faßbender K, Conconi MT, Parnigotto PP, Schäfer KH. Maintenance of the enteric neural stem cell niche by bacterial Lipopolysaccarides, Journal of Cellular and Molecular Medicine, 2014, doi: 10.1111/jcmm.12292.

Kuhne S., Strieth D., Lakatos M., Muffler K. & Ulber R. (2014) A new photobioreactor concept enabling the production of desiccation induced biotechnological products using terrestrial cyanobacteria. Journal of Biotechnology 192, Part A: 28-33.

Muffler K., Lakatos M., Schlegel C., Strieht D., Kuhne S. & Ulber R. (2014) Application of biofilm bioreactors in white biotechnology. Advances in Biochemical Engineering/ Biotechnology 146: 123-161.

Brigadski,T. & Lessmann,V. BDNF: a regulator of learning and memory processes with clinical potential. e-Neuroforum 5, 1-11 (2014).

Henke J, Erkel G, Brochhausen C, Kleinert H, Schwarting A, Menke, J, Pautz, A. The fungal lactone oxacyclododecindione is a potential new therapeutic substance in the treatment of lupus-associated kidney disease. Kidney international 2014; 86: 780-789.

Felix S, Sandjo LP, Opatz T, Erkel G. Anti-inflammatory drimane sesquiterpene lactones from an Aspergillus species. Bioorg Med Chem. 2014; 22: 2912-2918.

2013

Nagahara, A.H., Mateling, M., Kovacs, I., Wang, L., Eggert, S., Rockenstein, E., Koo, EH., Masliah, E., Tuszynski., M.H. Early BDNF Treatment Ameliorates Cell Loss in the Entorhinal Cortex of APP Transgenic Mice, J Neurosci 2013 Sep 25;33(39):15596-602

Jung, HJ., Kim, YJ., Eggert, S., Chung, KC., Choi, KS., Park SA. Age-dependent increases in tau phosphorylation in the brains of type 2 diabetic rats correlate with a reduced expression of p62. Exp Neurol 2013 Jul 29;248C:441-450

Semar S, Klotz M, Letiembre M, Van Ginneken C, Braun A, Jost V, Bischof M, Lammers WJ, Liu Y, Fassbender K, Wyss-Coray T, Kirchhoff F, Schäfer KH. Changes of the enteric nervous system in Amyloid Precursor Protein transgenic mice correlate with disease progression. Journal of Alzheimers Disease, 2013, 36(1):7-20. doi: 10.3233/JAD-120511.

Thyrock A, Ossendorf E, Stehling M, Kail M, Kurtz T, Pohlentz G, Waschbüsch D, Eggert S, Formstecher E, Müthing J, Dreisewerd K, Kins S, Goud B, Barnekow A. A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6. PLoS One. 2013 May 30;8(5):e64149. doi: 10.1371/journal.pone.0064149. PMID: 23737971; PMCID: PMC3667844.

Demir IE, Schäfer KH, Tieftrunk E, Friess H, Ceyhan GO. Neural plasticity in the gastrointestinal tract: chronic inflammation, neurotrophic signals and hypersensitivity. Acta Neuropathol. 2013. 125(4):491-509.

Kuhne S., Strieth D., Weber A., Muffler K., Lakatos M. & Ulber R. (2013) Screening of two terrestrial cyanobacteria for biotechnological production processes in shaking flasks, bubble columns, and stirred tank reactors. Journal of Applied Phycology 26(4):1639-1648.

Kuhne S., Lakatos M, Foltz S., Muffler K. & Ulber R. (2013) Characterization of terrestrial cyanobacteria to increase process efficiency in low energy consuming production processes. Sustainable Chemical Processes 1(1): 1-6.

Máguas C., Pinho P., Branquinho C., Hartard B. & Lakatos M. (2013) Carbon-Water-Nitrogen relationships between lichens and the atmosphere: Tools to understand metabolism and ecosystem change. MycoKeys 6: 95-106.

Rudolph K, Serwe A, Erkel G (2013). Inhibition of TGF-β signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone. Cytokine 2013; 61: 285-296.

2012

Grimm MO, Rothhaar TL, Grösgen S, Burg VK, Hundsdörfer B, Haupenthal VJ, Friess P, Kins S, Grimm HS, Hartmann T. Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP). J Nutr Biochem. 2012 Oct;23(10):1214-23. doi: 10.1016/j.jnutbio.2011.06.015. Epub 2011 Dec 29. PMID: 22209004.

Isbert S, Wagner K, Eggert S, Schweitzer A, Multhaup G, Weggen S, Kins S, Pietrzik CU. APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms. Cell Mol Life Sci. 2012 Apr;69(8):1353-75. doi: 10.1007/s00018-011-0882-4. Epub 2011 Nov 22. PMID: 22105709; PMCID: PMC3314181.

Brunholz S, Sisodia S, Lorenzo A, Deyts C, Kins S, Morfini G. Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells. Exp Brain Res. 2012 Apr;217(3-4):353-64. doi: 10.1007/s00221-011-2870-1. Epub 2011 Sep 30. PMID: 21960299; PMCID: PMC3670699.

Baumkötter F, Wagner K, Eggert S, Wild K, Kins S. Structural aspects and physiological consequences of APP/APLP trans-dimerization. Exp Brain Res. 2012 Apr;217(3-4):389-95. doi: 10.1007/s00221-011-2878-6. Epub 2011 Sep 28. PMID: 21952790; PMCID: PMC3308009.

Riemer J, Kins S. Axonal transport and mitochondrial dysfunction in Alzheimer's disease. Neurodegener Dis. 2013;12(3):111-24. doi: 10.1159/000342020. Epub 2012 Sep 28. PMID: 23037012.

Tyan, SH., Shih, AY., Walsh, JJ., Maruyama, H., Sarsoza, F., Ku, L., Eggert, S., Hof, PR., Koo, EH., Dickstein, DL. Amyloid precursor protein (APP) regulates synaptic structure and function. Mol and Cell Neurosci 2012 51(1-2):43-52

Midthune, B., Tyan, SH., Walsh, JJ., Sarsoza, F., Eggert, S., Hof, PR., Dickstein, DL., Koo, EH. Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function. Mol and Cell Neurosci 2012 49(4):448-55

Kuhne S., Muffler K., Lakatos M., Ulber R. (2012) Algae biotechnology V1.01 Innovative Photobioreactor for Cultivation of terrestrial Cyanobacteria. Chemie Ingenieur Technik 84:1178-1428.

Lakatos M., Obregón A., Büdel B. & Bendix J. (2012) Midday dew - an overlooked factor enhancing photosynthetic activity of corticolous epiphytes in a wet tropical forest. New Phytologist 194(1): 245-253.

2011

Van Ginneken CJ, Schäfer KH, Van Dam D, Huygelen V; De Deyn PP, Morphological changes in the enteric nervous system of aging and APP23 transgenic mice. Brain Res. 2011 Mar 10;1378:43-53. doi: 10.1016/j.brainres.2011.01.030.

Haschke G., Schäfer K.-H and Diener M Effects of butyrate on membrane potential, ionic currents and intracellular Ca-concentration in cultured myenteric neurones. Neurogastroenterology and Motility, 14, 1-10, 2002.

Kukar, TL., Ladd, TB., Robertson, P., Pintchovski, SA., Moore, B., Bann, MA., Ren, Z., Jansen-West, K., Malphrus, K., Eggert, S., Maruyama, H., Cottrell, BA., Das, P., Basi, GS., Koo, EH., Golde, TE. Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region. J Biol Chem 2011 286(46), 39804-12

Serwe A, Rudolph K, Anke T, Erkel G. Inhibition of TGF-β signaling, vasculogenic mimicry and proinflammatory gene expression by isoxanthohumol. Invest New Drugs 2011; DOI: 10.1007/s10637-011-9643-3.

2009 and before

Szodorai A, Kuan YH, Hunzelmann S, Engel U, Sakane A, Sasaki T, Takai Y, Kirsch J, Müller U, Beyreuther K, Brady S, Morfini G, Kins S. APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle. Version 2. J Neurosci. 2009 Nov 18;29(46):14534-44. doi: 10.1523/JNEUROSCI.1546-09.2009 . PMID: 19923287 ; PMCID: PMC2849269.

Eggert, S., Midthune, B., Cottrell, B., Koo, E.H. Induced dimerization of APP leads to decreased Amyloid-β protein (Aβ ) production. J Biol Chem 2009 284(42), 28943-52

Jung M, Triebel S, Anke T, Richling E, Erkel G Influence of apple polyphenols on inflammatory gene expression. Mol Nutr Food Res 2009; 53: 1263–1280.

 

DeBoer SR, You Y, Szodorai A, Kaminska A, Pigino G, Nwabuisi E, Wang B, Estrada-Hernandez T, Kins S, Brady ST, Morfini G. Conventional kinesin holoenzymes are composed of heavy and light chain homodimers. Biochemistry. 2008 Apr 15;47(15):4535-43. doi: 10.1021/bi702445j . Epub 2008 Mar 25. PMID: 18361505 ; PMCID: PMC2644488.

Erkel G, Belahmer H, Serwe A, Kunz H, Kolshorn H, Liermann J, Opatz T (2008) Oxacyclododecindione, a novel inhibitor of IL-4 signaling from Exserohilum rostratum, Journal of Antibiotics 61, 285-290.

 

Back S, Haas P, Tschäpe JA, Gruebl T, Kirsch J, Müller U, Beyreuther K, Kins S. beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment. J Neurosci Res. 2007 Sep;85(12):2580-90. doi: 10.1002/jnr.21239 . PMID: 17335075 .

Rusu P, Jansen A, Soba P, Kirsch J, Löwer A, Merdes G, Kuan YH, Jung A, Beyreuther K, Kjaerulff O, Kins S. Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity. Eur J Neurosci. 2007 Feb;25(4):1079-86. doi: 10.1111/j.1460-9568.2007.05341.x . PMID: 17331204 .

Dojani S., Lakatos M., Rascher U., Wanek W, Lüttge U. & Büdel B. (2007) Nitrogen input by cyanobacterial biofilms of an inselberg into a tropical rainforest in French Guiana, Flora 202 (7): 521-529.

 

Kuan YH, Gruebl T, Soba P, Eggert S, Nesic I, Back S, Kirsch J, Beyreuther K, Kins S. PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2. J Biol Chem. 2006 Dec 29;281(52):40114-23. doi: 10.1074/jbc.M605407200 . Epub 2006 Oct 18. PMID: 17050537 .

Kins S, Lauther N, Szodorai A, Beyreuther K. Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease. Neurodegener Dis. 2006;3(4-5):218-26. doi: 10.1159/000095259 . PMID: 17047360.Kins S, Beyreuther K. Teasing out the tangles. Nat Med. 2006 Jul;12(7):764-5; discussion 765. doi: 10.1038/nm0706-764 . PMID: 16829938 .

Götz J, Ittner LM, Kins S. Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease? J Neurochem. 2006 Aug;98(4):993-1006. doi: 10.1111/j.1471-4159.2006.03955.x . Epub 2006 Jun 19. PMID: 16787410 .

Hörster F, Schwab MA, Sauer SW, Pietz J, Hoffmann GF, Okun JG, Kölker S, Kins S. Phenylalanine reduces synaptic density in mixed cortical cultures from mice. Pediatr Res. 2006 Apr;59(4 Pt 1):544-8. doi: 10.1203/01.pdr.0000203091.45988.8d . PMID: 16549526 .

Erratum in: EMBO J. 2006 Feb 8;25(3):653. PMID: 16193067 ; PMCID: PMC1276707.

 

Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, Löwer A, Langer A, Merdes G, Paro R, Masters CL, Müller U, Kins S, Beyreuther K. Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO J. 2005 Oct 19;24(20):3624-34. doi: 10.1038/sj.emboj.7600824 . Epub 2005 Sep 29.

von Rotz RC, Kins S, Hipfel R, von der Kammer H, Nitsch RM. The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease. Eur J Neurosci. 2005 Mar;21(5):1289-98. doi: 10.1111/j.1460-9568.2005.03977.x . PMID: 15813938 .

Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS. Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci. 2005 Mar 2;25(9):2386-95. doi: 10.1523/JNEUROSCI.3089-04.2005 . PMID: 15745965 ; PMCID: PMC6726084.

 

Eggert, S., Paliga, K., Soba, P., Evin, G. Masters, C.L., Weidemann, A., and Beyreuther, K. The proteolytic processing of the Amyloid Precursor Protein gene family members APLP-1 and APLP-2 involves α-, β-, γ- and ε-like cleavages. Modulation of APLP-1 processing by glycosylation. J Biol Chem 2004 279(18), 18146-56 Corresponding author

 

Kins S, Kurosinski P, Nitsch RM, Götz J. Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice. Am J Pathol. 2003 Sep;163(3):833-43. doi: 10.1016/S0002-9440(10)63444-X . PMID: 12937125 ; PMCID: PMC1868255.

Walsh, DM., Fadeeva, JV., LaVoie, MJ., Paliga, K., Eggert, S., Kimberly, WT., Wasco, W., Selkoe, DJ. Gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry 2003 42(22), 6664-73

 

Schmidt K, Kins S, Schild A, Nitsch RM, Hemmings BA, Götz J. Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A. Eur J Neurosci. 2002 Dec;16(11):2039-48. doi: 10.1046/j.1460-9568.2002.02274.x . PMID: 12473071 .

Fuhrmann JC, Kins S, Rostaing P, El Far O, Kirsch J, Sheng M, Triller A, Betz H, Kneussel M. Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes. J Neurosci. 2002 Jul 1;22(13):5393-402. doi: 10.1523/JNEUROSCI.22-13-05393.2002 . PMID: 12097491 ; PMCID: PMC6758200.

Müller U, Kins S. APP on the move. Trends Mol Med. 2002 Apr;8(4):152-5. doi: 10.1016/s1471-4914(02)02320-1 . PMID: 11927267 .

Evin, G., Holsinger, D.R.M., Eggert, S., Weidemann, A., Canterford, L., Hoke, D., Gandy, S., McLean, C., Beyreuther, K., and Masters, C.L. Carboxyl-Terminal Fragments of the Amyloid Precursor Protein in Alzheimer’s Disease Brain: Detection of γ-Secretase Products. Brain Aging 2002 2, 61-66

Weidemann, A., Eggert, S., Reinhard, F.B.M., Vogel, M., Paliga, K., Baier,G., Masters, C.L., Beyreuther,K., and Evin, G. A novel ε-Cleavage within the Transmembrane Domain of the Alzheimer Amyloid Protein Demonstrates Homology with Notch Processing. Biochemistry 2002 41(8), 2825-2835

 

Grosskreutz Y, Hermann A, Kins S, Fuhrmann JC, Betz H, Kneussel M. Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin. Biol Chem. 2001 Oct;382(10):1455-62. doi: 10.1515/BC.2001.179 . PMID: 11727829 .

Steinhoff T, Moritz E, Wollmer MA, Mohajeri MH, Kins S, Nitsch RM. Increased cystatin C in astrocytes of transgenic mice expressing the K670N-M671L mutation of the amyloid precursor protein and deposition in brain amyloid plaques. Neurobiol Dis. 2001 Aug;8(4):647-54. doi: 10.1006/nbdi.2001.0412 . PMID: 11493029 .

Kins S, Crameri A, Evans DR, Hemmings BA, Nitsch RM, Gotz J. Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. J Biol Chem. 2001 Oct 12;276(41):38193-200. doi: 10.1074/jbc.M102621200 . Epub 2001 Jul 25. PMID: 11473109 .

 

Ramming M, Kins S, Werner N, Hermann A, Betz H, Kirsch J. Diversity and phylogeny of gephyrin: tissue-specific splice variants, gene structure, and sequence similarities to molybdenum cofactor-synthesizing and cytoskeleton-associated proteins. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10266-71. doi: 10.1073/pnas.97.18.10266 . PMID: 10963686 ; PMCID: PMC27865.

Kins S, Betz H, Kirsch J. Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin. Nat Neurosci. 2000 Jan;3(1):22-9. doi: 10.1038/71096 . PMID: 10607391 .

Kins S, Kuhse J, Laube B, Betz H, Kirsch J. Incorporation of a gephyrin-binding motif targets NMDA receptors to gephyrin-rich domains in HEK 293 cells. Eur J Neurosci. 1999 Feb;11(2):740-4. doi: 10.1046/j.1460-9568.1999.00527.x . PMID: 10051776 .