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Karl-Herbert Schäfer, Prof., Dr. med

Professor of Biotechnology in Mikrosystemstechnology, University of Applied Sciences Kaiserslautern

Date of Birth:             10.04.57      




Since 2017

06/2008 - 12/2008      09/2001             

07/1999 - 09/1999               

1995 - 1999

1992 - 1993

1991 - 1995


1988 - 1991

1987 - 1988




1980 - 1986

Vicepresident Research and Transfer University of Applied Sciences Kaiserslautern


Visiting Professor University Stanford, California, USA

Appointment C3-Professorship, Biotechnology, University of Applied Sciences Kaiserslautern.
Head of Working Group Enteric Nervous System of Pediatric Surgery, University Heidelberg, Hospital Mannheim

Research Resident, Department of Pediatric Surgery, University Heidelberg, Hospital Mannheim

Assistant Professor, Anatomy Homburg, Consultant in Anatomy

Research Sabbatical, University College London

Research Assistant, Department of Anatomy Homburg

Specialisation in Emergeny Medicine

Resident, Department of Surgery, St.Josef-Krankenhaus      

Research Assistant, Department of Anatomy Homburg


Habilitation: „Isoliation and cultivation of myenteric plexus: a new approach to investigate the postnatal development of the enteric nervous system in men and rat."

Doctoral Thesis "Morphology of GABA-ergic Neurones in the medial preoptic nucleus (MPN) of the rat"

Study of human medicine at the University of Saarland, Homburg
Approbation Oktober 1986


Member of Society for Neurosciences, Anatomical Society Germany, Neurogastroenterology and Motility Society Germany, International Society for Autonomous Neurosciences, Sout-West-Germany SAR Medical Doctor Assocication, German Society of Stem Cell Researh

Awards and Honors:

  • Martin-Wienbeck Award 2014
  • Novartis Award, Experimental Pediatric Surgery Symposium Graz, 2003
  • Nomination Soave Award of the Colorectal Club, Stockholm1999
  • Multiple Posterawards

Topic specific publications

1   Endres K and Schäfer KH. Influence of Commensal Microbiota on the Enteric Nervous System and Its Role in Neurodegenerative Diseases. Journal of Innate Immunity. 2018 May 9:1-9. doi: 10.1159/000488629.

2   Schwiertz A, Spiegel J, Dillmann U, Grundmann D, Bürmann J, Faßbender K, Schäfer KH, Unger MM. Fecal markers of intestinal inflammation and intestinal permeability are elevated in Parkinson's disease. Parkinsonism and Related Disorders. 2018 doi: 10.1016/j.parkreldis.2018.02.022.

3   Schreiber D, Marx L, Felix S, Clasohm J, Weyland M, Schäfer M, Klotz M, Lilischkis R, Erkel G, Schäfer KH. Anti-inflammatory Effects of Fungal Metabolites in Mouse Intestine as Revealed by In vitroModels. Frontiers in Physiology. 2017 Aug 7;8:566. doi: 10.3389/fphys.2017.00566. eCollection 2017.

4   Brandscheid C, Schuck F, Reinhardt S, Schäfer KH, Pietrzik CU, Grimm M, Hartmann T, Schwiertz A, Endres K. Altered  Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model. J Alzheimers Disease. 2017;56(2):775-788. doi: 10.3233/JAD-160926.

5   Unger MM, Spiegel J, Dillmann KU, Grundmann D, Philippeit H, Bürmann J, Faßbender K, Schwiertz A, Schäfer KH. Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls. Parkinsonism and Related Disorders. 2016 Aug 26. pii: S1353-8020(16)30323-6. doi: 10.1016/j.parkreldis.2016.08.019.

6   Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schäfer KH et al.. White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Developmental Biology. 2016 Apr 5. pii: S0012-1606(16)30111-7. doi: 10.1016/j.ydbio.2016.04.001.

7   Isolation of high-purity myenteric plexus from adult human and mouse gastrointestinal tract. Grundmann D, Klotz M, Rabe H, Glanemann M, Schäfer KH.    
Scientific  Report
. 2015 Mar 20;5:9226. doi: 10.1038/srep09226.

8   Schuster A, Klotz M, Schwab T, Di Liddo R, Bertalot T, Schrenk S, Martin M, Nguyen TD, Nguyen TNQ, Gries M, Faßbender K, Conconi MT, Parnigotto PP, Schäfer KH. Maintenance of the enteric neural stem cell niche by bacterial Lipopolysaccharides, Journal of Cellular and Molecular Medicine, 2014, doi: 10.1111/jcmm.12292.

9   Semar S, Klotz M, Letiembre M, Van Ginneken C, Braun A, Jost V, Bischof M, Lammers WJ, Liu Y, Fassbender K, Wyss-Coray T, Kirchhoff F, Schäfer KH. Changes of the enteric nervous system in Amyloid Precursor Protein transgenic mice correlate with disease progression. Journal of Alzheimers Disease, 2013, 36(1):7-20. doi: 10.3233/JAD-120511.

10  Demir IE, Schäfer KH, Tieftrunk E, Friess H, Ceyhan GO. Neural plasticity in the gastrointestinal tract: chronic inflammation, neurotrophic signals and hypersensitivity. Acta Neuropathologica. 2013. 125(4):491-509.