Vizepräsident für Forschung, Forschungsschwerpunkt Integrierte Miniaturisierte Systeme FB IMST, Projekt Charakterisierung enterischer neuronaler Stammzellen FB IMST, Projekt Darmfunktionsdiagnostik FB IMST, Projekt ImmENS, Interaktion des Mikrobioms mit dem Enterischen Nervensystem (ENS), Projekt Intrinsische Stammzellen FB IMST, Projekt Modifizierung und Anwendung von Multielektrodenarrays zur Erfassung neuraler Signale des ENS, Projekt Offene Digitalisierungsallianz für die Pfalz, AG ENS, Projekt Transplantation neuraler Stammzellen zur Behandlung von Aganglionosen, Projekt Untersuchungen der Darmmotalität und des Darmnervensystems im Kontekt neurodegenerativer Erkrankungen, Working Group Enteric Nervous System
- +49 631 3724-5418KarlHerbert.Schaefer(at)hs-kl(dot)de
- Campus Zweibrücken
- Room H136/ H205
Biography:
| Since 2017 | Vicepresident Research and Transfer University of Applied Sciences Kaiserslautern | |
| 06/2008 - 12/2008 | Visiting Professor University Stanford, California, USA | |
| 09/2001 | Appointment C3-Professorship, Biotechnology, University of Applied Sciences Kaiserslautern. Head of Working Group Enteric Nervous System of Pediatric Surgery, University Heidelberg, Hospital Mannheim | |
| 07/1999 - 09/1999 | Research Resident, Department of Pediatric Surgery, | |
| 1995 - 1999 | Assistant Professor, Anatomy Homburg, Consultant in Anatomy | |
| 1992 - 1993 | Research Sabbatical, University College London | |
| 1991 - 1995 | Research Assistant, Department of Anatomy Homburg | |
| 1990 | Specialisation in Emergeny Medicine | |
| 1988 - 1991 | Resident, Department of Surgery, St.Josef-Krankenhaus Neunkirchen | |
| 1987 - 1988 | Research Assistant, Department of Anatomy Homburg | |
| 2000 | Habilitation: „Isoliation and cultivation of myenteric plexus: a new approach to investigate the postnatal development of the enteric nervous system in men and rat." | |
| 1993 | Doctoral Thesis "Morphology of GABA-ergic Neurones in the medial preoptic nucleus (MPN) of the rat" | |
| 1980 - 1986 | Study of human medicine at the University of Saarland, Homburg Approbation Oktober 1986 |
Member of Society for Neurosciences, Anatomical Society Germany, Neurogastroenterology and Motility Society Germany,
International Society for Autonomous Neurosciences, Sout-West-Germany SAR Medical Doctor Assocication, German Society of Stem Cell Researh
Awards and Honors:
- Martin-Wienbeck Award 2014
- Novartis Award, Experimental Pediatric Surgery Symposium Graz, 2003
- Nomination Soave Award of the Colorectal Club, Stockholm1999
- Multiple Posterawards
Topic specific publications
1 Endres K and Schäfer KH. Influence of Commensal Microbiota on the Enteric Nervous System and Its Role in Neurodegenerative Diseases. Journal of Innate Immunity. 2018 May 9:1-9. doi: 10.1159/000488629.
2 Schwiertz A, Spiegel J, Dillmann U, Grundmann D, Bürmann J, Faßbender K, Schäfer KH, Unger MM. Fecal markers of intestinal inflammation and intestinal permeability are elevated in Parkinson's disease. Parkinsonism and Related Disorders. 2018 doi: 10.1016/j.parkreldis.2018.02.022.
3 Schreiber D, Marx L, Felix S, Clasohm J, Weyland M, Schäfer M, Klotz M, Lilischkis R, Erkel G, Schäfer KH. Anti-inflammatory Effects of Fungal Metabolites in Mouse Intestine as Revealed by In vitroModels. Frontiers in Physiology. 2017 Aug 7;8:566. doi: 10.3389/fphys.2017.00566. eCollection 2017.
4 Brandscheid C, Schuck F, Reinhardt S, Schäfer KH, Pietrzik CU, Grimm M, Hartmann T, Schwiertz A, Endres K. Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model. J Alzheimers Disease. 2017;56(2):775-788. doi: 10.3233/JAD-160926.
5 Unger MM, Spiegel J, Dillmann KU, Grundmann D, Philippeit H, Bürmann J, Faßbender K, Schwiertz A, Schäfer KH. Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls. Parkinsonism and Related Disorders. 2016 Aug 26. pii: S1353-8020(16)30323-6. doi: 10.1016/j.parkreldis.2016.08.019.
6 Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schäfer KH et al.. White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Developmental Biology. 2016 Apr 5. pii: S0012-1606(16)30111-7. doi: 10.1016/j.ydbio.2016.04.001.
7 Isolation of high-purity myenteric plexus from adult human and mouse gastrointestinal tract. Grundmann D, Klotz M, Rabe H, Glanemann M, Schäfer KH.
Scientific Report. 2015 Mar 20;5:9226. doi: 10.1038/srep09226.
8 Schuster A, Klotz M, Schwab T, Di Liddo R, Bertalot T, Schrenk S, Martin M, Nguyen TD, Nguyen TNQ, Gries M, Faßbender K, Conconi MT, Parnigotto PP, Schäfer KH. Maintenance of the enteric neural stem cell niche by bacterial Lipopolysaccharides, Journal of Cellular and Molecular Medicine, 2014, doi: 10.1111/jcmm.12292.
9 Semar S, Klotz M, Letiembre M, Van Ginneken C, Braun A, Jost V, Bischof M, Lammers WJ, Liu Y, Fassbender K, Wyss-Coray T, Kirchhoff F, Schäfer KH. Changes of the enteric nervous system in Amyloid Precursor Protein transgenic mice correlate with disease progression. Journal of Alzheimers Disease, 2013, 36(1):7-20. doi: 10.3233/JAD-120511.
10 Demir IE, Schäfer KH, Tieftrunk E, Friess H, Ceyhan GO. Neural plasticity in the gastrointestinal tract: chronic inflammation, neurotrophic signals and hypersensitivity. Acta Neuropathologica. 2013. 125(4):491-509.