1Schuck F, Wolf D, Fellgiebel A, Endres K. Increase of α-Secretase ADAM10 in Platelets Along Cognitively Healthy Aging. J Alzheimers Dis. 2016;50(3):817-26. doi: 10.3233/JAD-150737. 2Anna Wierczeiko, David Fournier, Hristo Todorov, Susanne Klingenberg, Kristina Endres, Susanne Gerber; Decoupling of DNA Methylation Status and Gene Expression Leve
1 Isolation of high-purity myenteric plexus from adult human and mouse gastrointestinal tract. Grundmann D, Klotz M, Rabe H, Glanemann M, Schäfer KH.Sci Rep. 2015 Mar 20;5:9226. doi: 10.1038/srep09226. 2 Demir IE, Schäfer KH, Tieftrunk E, Friess H, Ceyhan GO. Neural plasticity in the gastrointestinal tract: chronic inflammation, neurotrophic sig
AGENS
The Enteric Nervous System Research Group (AGENS) headed by Prof. KH Schäfer (HS KL) has been working for years on the characterization of the ENS in the context of development, changes in disease patterns, or the use of the enteric neural stem cells contained in it.1,2 First indications of an influence of local inflammation on these neural
A central focus of the group is the role of the ENS in neurodegenerative diseases. Here, i.e. it could be shown that the ENS also affects the intestinal nervous system in a disease that tends to affect cognitive abilities, such as Alzheimer's disease. In an animal model, changes in the ENS were observed long before changes in the CNS5. This also
Neuroforum 2020; aop Presentation of scientific institutions Kristina Endres* and Simone Eggert* Forschungskolleg “NeurodegX” https://doi.org/10.1515/nf-2020-0019 „Isolation and characterization of neuroprotective substances from fungi and cyanobacteria as potential substances for treatment of neurodegenerative diseases“ In 2018, a new concept
