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Veröffentlichungen

2014-2010

Götze S, Coersmeyer M, Müller O, Sievers S: Histone acetylase inhibitors induce attenuation of Wnt signaling and TCF7L2 depletion in colorectal carcinoma cells. International Journal of Oncology 45(4), 1715-1723 (2014). www.spandidos-publications.com/10.3892/ijo.2014.2550

Balke D, Zieten I, Strahl A, Müller O, Müller S: Design and characterization of a twin ribozyme for the repair of a deletion mutation within the oncogenic CTNNB1-DS45-mRNA. ChemMedChem 9(9), 2128-2137 (2014). doi.org/10.1002/cmdc.201402166

Apfel J, Reischmann P, Müller O: A new fluorescence-based reporter gene vector as a atool for analyzing and fishing cells with activated Wnt signaling pathway. ISRN Oncology Article ID 603129 (2013). doi.org/10.1155/2013/603129

Vlad-Fiegen A, Langerak A, Eberth S, Müller O: The Wnt pathway destabilizes adherens junctions and promotes cell migration via b-catenin and its target gene cyclin D1. FEBS Open Bio 2, 26-31 (2012). doi.org/10.1016/j.fob.2012.02.004

Drude I, Strahl A, Galla D, Müller O, Müller S: Design of hairpin ribozyme variants with improved activity for poorly processed substrates. The FEBS Journal: 278, 622-633 (2011). doi.org/10.1111/j.1742-4658.2010.07983.x

Götze S, Wolter M, Reifenberger G, Müller O, Sievers S: Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas. International Journal of Cancer 126, 2584-2593 (2010). doi.org/10.1002/ijc.24981

Lanckohr C, Debiec-Richter M, Müller O, Homann H, Lehnhardt M, Herter P, Kuhnen C: Gardner fibroma: Case report with morphologic, molecular biological and genetic analysis and discussion of a relatively new soft tissue tumor entity. Der Pathologe 1, 1-9 (2010). doi.org/10.1007/s00292-009-1260-y

2009-2008

Götze S, Feldhaus V, Traska T, Wolter M, Reifenberger G, Tannapfel A, Kuhnen C, Martin D, Müller O, Sievers S: ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma. BMC Cancer 9, 447 (2009). doi.org/10.1186/1471-2407-9-447

Marelli MM, Moretti RM, Mai S, Müller O, van Groeninghen J, Limonta P: Novel insights into GnRH receptor activity: Role in the control of human glioblastoma cell proliferation. Oncology reports 21: 1277-1282 (2009). doi.org/10.3892/or_00000351

Röhrs S, Kutzner N, Vlad A, Grunwald T, Ziegler S, Müller O: Chronological expression of Wnt target genes Ccnd1, Myc, Cdkn1a, Tfrc, Plf1 and Ramp3. Cell Biology International 33: 501-508 (2009). dx.doi.org/10.1016/j.cellbi.2009.01.016

Daigeler A, Klein-Hitpass L, Stricker I, Müller O, Kuhnen C, Chromik AM, Steinstraesser L, Goertz O, Steinau HU, Lehnhardt M: Malignant fibrous histiocytoma – pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study. Langenbeck’s Archives of Surgery 394(3): 261-275 (2009). doi.org/10.1007/s00423-009-0465-0

Tickenbrock L, Hehn S, Sargin B, Choudhary C, Bäumer N, Bürger H, Schulte B, Müller O, Berdel WE, Müller-Tidow C, Serve H: Activation of Wnt signalling in acute leukaemia by induction of Frizzled-4. International Journal of Oncology 33(6): 1215-1221 (2008). dx.doi.org/10.3892/ijo_00000111

Daigeler A, Lehnhardt M, Müller O, Steinau HU, Homann H, Hauser J, Chromik A, Klein-Hitpass L: Heterogeneous in vitro effects of doxorubicin on gene expression in primary human liposarcoma cultures. BMC Cancer 8: 313 (2008). dx.doi.org/10.1186%2F1471-2407-8-313

Sievers S, Fritzsch C, Kuhnen C, Müller O: SPMSP: Solid-phase PCR with colorimetric read-out for quantitative methylation analysis. Anticancer Research 28: 2055-2060 (2008).

Csepregi A, Röcken C, Hoffmann J, Ping G, Saliger S, Müller O, Schneider-Stock R, Kutzner N, Roessner A, Malfertheiner P, Ebert MP: APC promoter methylation and protein expression in hepatocellular carcinoma. Journal of Cancer Research and Clinical Oncology 134(5): 579-589 (2008). doi.org/10.1007/s00432-007-0321-y

Wehner F, Nören-Müller A, Müller O, Reis-Correa I, Giannis A, Waldmann H: Indoloquinolizidine Derivatives as Novel and Potent Apoptosis Inducers and Cell-Cycle Blockers. ChemBioChem 9: 401-405 (2008). ChemBioChem 9: Cover Picture. doi.org/10.1002/cbic.200700558

2007-2006

Köster MP, Müller O, Pollerberg E: Adenomatous Polyposis Coli (APC) is differentially distributed in growth cones and modulates their local stability and steering. Journal of Neuroscience 27(46): 12590-12600 (2007). doi.org/10.1523/jneurosci.2250-07.2007

Fürstner A, Nevado C, Wasser M, Tremblay M, Chevrier C, Teply F, Aïssa C, Moulin E, Müller O: Total synthesis of Iejimalide A-D and assessment of the remarkable actin-depolymerizing capacity of these polyene macrolides. Journal of the American Chemical Society 129(29): 9150-9161 (2007). doi.org/10.1021/ja072334v

Lessmann T, Leuenberger MG, Menninger S, Lopez-Canet M, Müller O, Hümmer S, Bormann J, Korn K, Fava E, Zerial M, Mayer TU, Waldmann H: Natural Product-derived Modulators of Cell Cycle Progression and Viral Entry by Enantioselective Oxa Diels-Alder Reactions on the Solid Phase. Chemistry & Biology 14(4): 443-451 (2007). dx.doi.org/10.1016/j.chembiol.2007.02.008

Fürstner A, Nagano T, Müller C, Seidel G, Müller O: Total synthesis and evaluation of the actin-binding properties of microcarpalide and a focused library of analogues. Chemistry 13: 1452-1462 (2007). doi.org/10.1002/chem.200601370

Ziegler S, Röhrs S, Tickenbrock L, Langerak A, Chud S, Feldmann I, Jakubowski N, Müller O: 24p3 is regulated by the Wnt pathway independently from iron. Cancer Genetics and Cytogenetics 174: 16-23 (2007). dx.doi.org/10.1016/j.cancergencyto.2006.11.004

Fürstner A, Kirk D, Fenster MDB, Aïssa C, De Souza D, Nevado C, Tuttle T, Thiel W, Müller O: Latrunculin Analogues with Improved Biological Profiles by Diverted Total Synthesis: Preparation, Evaluation and Computational Analysis. Chemistry 13: 135-140 (2007). doi.org/10.1002/chem.200601136

Sievers S, Fritzsch C, Kutzner N, Lehnhardt M, Kuhnen C, Müller O: Hypermethylation of the APC Promoter but lack of APC mutations in Myxoid/Round-cell Liposarcoma. International Journal of Cancer 119: 2347-2352 (2006). doi.org/10.1002/ijc.22117

Shahmoradgoli M, Müller O, Kutzner, N, Noorinayer B, Zali MR: Gene Symbol: APC. Disease: Familial adenomatous polyposis coli. Human Genetics 118(6): 776 (2006)

Sievers S, Fritzsch C, Grzegorczyk M, Kuhnen C, Müller O: Absolute beta-catenin concentrations in Wnt pathway stimulated and non-stimulated cells. Biomarkers 11 (3): 270-278 (2006). doi.org/10.1080/13547500600633954

2005

Lumbierres M, Palomo JM, Kragol G, Röhrs S, Müller O, Waldmann H: Solid-Phase Synthesis of Lipidated Peptides. Chemistry 11: 7405-7415 (2005). doi.org/10.1002/chem.200500476

Becker CFW, Wacker R, Bouschen W, Seidel R, Kolaric B, Lang P, Schroeder H, Müller O, Niemeyer CM, Spengler B, Goody RS, Engelhard M: Protein-DNA Arrays as Tools for Detection of Protein-Protein Interactions by Mass Spectrometry. Angewandte Chemie 117: 7808-7812 (2005). Angewandte Chemie Int Edit 44: 7635-7639 (2005). doi.org/10.1002/cbic.201200597

Barun O, Kumar K, Sommer S, Langerak A, Mayer TU, Müller O, Waldmann H: Natural Product Guided Synthesis of a Spiroacetal Collection Reveals Modulators of Tubulin Cytoskeleton Integrity. European Journal of Organic Chemistry 22: 4773-4788 (2005). European Journal of Organic Chemistry 22 (2005): Cover Picture. doi.org/10.1002/ejoc.200500605

Lehnhardt M, Klein-Hitpass L, Kuhnen C, Homann HH, Daigeler A, Steinau HU, Röhrs S, Schnorr L, Steinstraesser L, Müller O: Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BioMedCentral Cancer 5: 74-90 (2005). doi.org/10.1186/1471-2407-5-74

Fürstner A, Kirk D, Fenster M, Aissa C, De Souza D, Müller O: Diverted Total Synthesis: Preparation of a Focused Library of Latrunculin Analogues and Evaluation of their Actin-Binding Properties. Proceedings of the National Academy of Science of the USA (PNAS) 102(23): 8103-8108 (2005). doi.org/10.1073/pnas.0501441102

Lehnhardt M, Muehlberger T, Kuhnen C, Brett D, Steinau HU, Joneidi Jafari H, Steinstraesser L, Müller O, Homann HH: Feasibility of Chemosensitivity Testing in Soft Tissue Sarcomas. World Journal of Surgical Oncology 3(20): 1-12 (2005). dx.doi.org/10.1186%2F1477-7819-3-20

Ziegler S, Röhrs S, Tickenbrock L, Möröy T, Klein-Hitpass L, Vetter IR, Müller O: Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation. The FEBS Journal 272(7): 1600-1615 (2005). doi.org/10.1111/j.1742-4658.2005.04581.x

Rosenbaum C, Röhrs S, Müller O, Waldmann H: Modulation of MRP-1-Mediated Multidrug Resistance by Indomethacin Analogues. Journal of Medicinal Chemistry 48(4): 1179-1187 (2005). doi.org/10.1021/jm0499099

Kutzner N, Hoffmann I, Linke C, Thienel T, Grzegorczyk M, Urfer W, Martin D, Winde G, Traska T, Hohlbach G, Müller KM, Kuhnen C, Müller O: Non-invasive colorectal cancer diagnosis by the combined application of molecular diagnosis and the faecal occult blood test. Cancer Letters 229: 33-41 (2005)

Chen J, Röcken C, Lofton-Day C, Schulz HU, Müller O, Kutzner N, Malfertheiner P, Ebert M: Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis. Carcinogenesis 26(1): 37-43 (2005). doi.org/10.1093/carcin/bgh280

2004-2003

Karaguni IM, Gourzoulidou E, Carpintero M, Langerak A, Klein-Hitpaß L, Möröy T, Winde G, Waldmann H, Müller O: SMAF-1 inhibits the APC/b-catenin pathway and shows properties similar to these of the tumor suppressor protein APC. ChemBioChem 5(9): 1267-1270 (2004). doi.org/10.1002/cbic.200400078

Waldmann H, Karaguni IM, Carpintero M, Gourzoulidou E, Herrmann C, Brockmann C, Oschkinat H, Müller O: Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway. Angewandte Chemie 116(4): 460-464 (2004). Angewandte Chemie Int Edit 43(4): 454-458 (2004). doi.org/10.1002/anie.200353089

Müller O, Gourzoulidou E, Carpintero M, Karaguni IM, Langerak A, Herrmann C, Möröy T, Klein-Hitpaß L, Waldmann H: Identification of potent Ras signaling inhibitors by Pathway-Selective Phenotype-Based Screening. Angewandte Chemie116(4): 456-460 (2004). Angewandte Chemie Int Edit 43(4): 450-454 (2004). doi.org/10.1002/anie.200352587

Rosenbaum C, Baumhof P, Mazitschek R, Müller O, Giannis A, Waldmann H: Synthesis and biological evaluation of an Indomethacin library reveals a new class of angiogenesis-related kinase inhibitors. Angewandte Chemie 116(3): 226-230 (2004). Angewandte Chemie Int Edit 43(2): 224-228 (2004). doi.org/10.1002/anie.200352582

Oliveira MJ, van Damme J, Lauwaet T, de Corte V, Bruyne G, Verschraegen G, Vaneechoutte M, Goethals M, Ahmadian MR, Müller O, Vandekerckhove J, Mareel M, Leroy A: b-Casein-derived Peptides, produced by bacteria, stimulate cancer cell invasion and motility. EMBO Journal 22(22): 6161-6173 (2003). doi.org/10.1093/emboj/cdg586

Thutewohl M, Kissau L, Popkirova B, Karaguni IM, Nowak T, Bate M, Kuhlmann J, Müller O, Waldmann H: Identification of mono- and bisubstrate inhibitors of protein farnesyltransferase and inducers of apoptosis from a pepticinnamin E library. Bioorganic & Medicinal Chemistry 11: 2617-2626 (2003). doi.org/10.1016/s0968-0896(03)00160-3

Andreyev HJN, Benamouzig R, Beranek M, Clarke P, Cunningham D, Norman AR, Giaretti W, de Goeij AFPM, Iacopetta BJ, Jullian E, Krtolica K, Lee JQ, Wang ST, Lees N, Al-Mulla F, Müller O, Pauly M, Pricolo V, Russo A, Troungos C, Urosevic N, Ward R: Mutant K-ras2 in serum. Gut 52(6): 915-916 (2003). doi.org/10.1136/gut.52.6.915-a

Ebert MPA, Yu J, Hoffmann J, Rocco A, Röcken C, Kahmann S, Müller O, Korc M, Sung JJ, Malfertheiner P: Loss of b-catenin expression in metastatic gastric cancer. Journal of Clinical Oncology 21(9): 1708-1714 (2003). dx.doi.org/10.1200/JCO.2003.10.017

Tickenbrock L, Kößmeier K, Rehmann H, Herrmann C, Müller O: Differences between the interaction of b-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acids repeats of the APC protein. Journal of Molecular Biology 327: 359-367 (2003). doi.org/10.1016/S0022-2836(03)00144-X

2002

Tickenbrock L, Cramer J, Vetter I, Müller O: Structure of the aminoterminal nuclear export domain of the APC tumor suppressor protein. Annals of the New York Academy of Science 973: 109-111 (2002). dx.doi.org/10.1111/j.1749-6632.2002.tb04616.x

Brohm D, Philippe N, Metzger S, Bhargava A, Müller O, Lieb F, Waldmann H: Solid-Phase synthesis of dysidiolide-derived protein phosphatase inhibitors. Journal of the American Chemical Society 124(44): 13171-13178 (2002). doi.org/10.1021/ja027609f

Debruyne P, Bruyneel E, Karaguni IM, Li X, Flatau G, Müller O, Zimber A, Gespach C, Mareel M: Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of multiple oncogenic signalling pathways. Oncogene 21(44):6740-6750 (2002). doi.org/10.1038/sj.onc.1205729

Thutewohl M, Kissau LA, Popkirova B, Karaguni I-M, Nowak T, Bate M, Kuhlmann J, Müller O, Waldmann H: Solid-phase synthesis and biological evaluation of a Pepticinnamine E library. Angewandte Chemie 114(19): 3768-3772 (2002). Angewandte Chemie Int Edit 41(19): 3616-3620 (2002).

Chtarbova S, Nimmrich I, Erdmann S, Herter P, Remmer M, Kitajewski J, Müller O: Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation. Biochemical Journal 367: 723-728 (2002). doi.org/10.1042/bj20020699

Tickenbrock L, Cramer J, Vetter I, Müller O: The coiled-coil region (amino acids 129-250) of the tumor suppressor protein Adenomatous Polyposis coli (APC). Its structure and interaction with chromosome maintenance region 1 (crm-1). Journal of Biological Chemistry 277: 32332-32338 (2002). doi.org/10.1074/jbc.M203990200

Karaguni IM, Herter P, Debruyne P, Chtarbova S, Kasprzynski A, Herbrand U, Ahmadian MR, Glüsenkamp KH, Winde G, Mareel M, Möröy T, Müller O: The new Sulindac derivative IND 12 reverses Ras-induced cell transformation. Cancer Research 62: 1718-1723 (2002).

Karaguni IM, Glüsenkamp KH, Langerak A, Geisen C, Ullrich V, Winde G, Möröy T, Müller O: New indene-derivatives with anti-proliferative properties. Bioorganic & Medicinal Chemistry Letters 12: 709-713 (2002). doi.org/10.1016/s0960-894x(01)00839-3

Brohm D, Metzger S, Bhargava A, Müller O, Lieb F, Waldmann H: Natural Products are Biologically Validated Starting Points in Structural Space for Compound Library Development: Solid Phase Synthesis of Dysidiolide-Derived Phosphatase Inhibitors. Angewandte Chemie 114(2): 319-323 (2002). Angewandte Chemie Int Edit 41(2): 307-311 (2002). Angewandte Chemie International Edition 41(2): Cover Picture (prämiert als Titelblatt des Jahres). doi.org/10.1002/1521-3773(20020118)41:2%3C307::aid-anie307%3E3.0.co;2-1

Kahmann S, Herter P, Kuhnen C, Müller KM, Muhr G, Martin D, Soddemann M, Müller O: A non-radioactive protein truncation test for sensitive detection of all stop and frameshift mutations. Human Mutation 19(2): 165-172 (2002). dx.doi.org/10.1002/humu.10024

Ebert MPA, Fei G, Kahmann S, Müller O, Yu J, Sung JJ, Malfertheiner P: Increased b-catenin mRNA levels and mutational alterations of the APC and b-catenin gene are present in intestinal-type gastric cancer. Carcinogenesis 23(1): 87-91 (2002). doi.org/10.1093/carcin/23.1.87

2001-2000

Andreyev HJ, Norman AR, Cunningham D, Oates J, Dix BR, Iacopetta BJ, Young J, Walsh T, Ward R, Hawkins N, Beranek M, Jandik P, Benamouzig R, Jullian E, Laurent-Puig P, Olschwang S, Müller O, et al.: Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. British Journal of Cancer 85(5): 692-696 (2001). doi.org/10.1054/bjoc.2001.1964

Leroy K, Duyckaerts C, Bovekamp L, Müller O, Anderton BH, Brion JP: Increase of Adenomatous Polyposis coli immunoreactivity is a marker of reactive astrocytes in Alzheimer’s disease and in other pathological conditions. Acta Neuropathologica 102: 1-10 (2001). dx.doi.org/10.1007/s004010000340

Nimmrich I, Erdmann S, Melchers U, Chtarbova S, Finke U, Hentsch S, Hoffmann I, Oertel M, Hoffmann W, Müller O: The novel ependymin related gene UCC1 is highly expressed in colorectal tumor cells. Cancer Letters 165: 71-79 (2001). doi.org/10.1016/s0304-3835(01)00390-1

Böse G, Kuhlmann J, Plass M, Müller O: Microplate ELISA assay for the detection of primary DNA alterations based on the interaction with UvrA/UvrB. Analytical Biochemistry 292: 1-7 (2001). doi.org/10.1006/abio.2001.5054

Nimmrich I, Erdmann S, Melchers U, Finke U, Hentsch S, Moyer MP, Hoffmann I, Müller O: Seven genes that are differentially transcribed in colorectal tumor and normal cell lines. Cancer Letters 160: 37-43 (2000). dx.doi.org/10.1016/S0304-3835(00)00553-X

Kuhnen C, Herter P, Müller O, Muehlberger T, Krause L, Homann H, Steinau HU, Müller KM: beta-catenin in soft tissue sarcomas: expression is related to proliferative activity in high-grade sarcomas.Modern Pathology 13(9): 1005-1013 (2000). doi.org/10.1038/modpathol.3880181

Erdmann KS, Kuhlmann J, Lessmann V, Herrmann L, Eulenburg V, Müller O, Heumann R: The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain. Oncogene 19: 3894-3901 (2000). doi.org/10.1038/sj.onc.1203725

Kuhnen C, Herter P, Monse H, Kahmann S, Muehlberger T, Vogt PM, Steinau HU, Müller KM, Müller O: APC and beta-catenin in alveolar soft part sarcoma (ASPS) – Immunohistochemical and molecular genetic analysis. Pathology Research and Practice 196: 299-304 (2000). doi.org/10.1016/s0344-0338(00)80059-x

1999-1998

Deka J, Herter P, Sprenger-Haußels M, Koosch S, Franz D, Müller KM, Kuhnen C, Hoffmann I, Müller O: The APC protein binds to A/T rich DNA sequences. Oncogene 18: 5654-5661 (1999). doi.org/10.1038/sj.onc.1202944

Herter P, Kuhnen C, Müller KM, Wittinghofer A, Müller O: Intracellular distribution of beta-catenin in colorectal adenomas, carcinomas and Peutz-Jeghers polyps. Journal of Cancer Research and Clinical Oncology 125: 297-304 (1999). doi.org/10.1007/s004320050277

Winde G, Lügering N, Glodny B, Schmid KW, Müller O, Senninger N, Osswald H: Decreased Her-2 tyrosine kinase expression in rectal mucosa of FAP patients following low-dose sulindac chemoprevention. Cancer Letters 134: 201-207 (1998). doi.org/10.1016/s0304-3835(98)00254-7

Kuhnen C, Herter P, Steinau H, Müller O, Müller KM: Intracellular distribution of beta-Catenin in soft tissue tumors. Verhandlungen der deutschen Gesellschaft für Pathologie 82: 322-326 (1998)

Hermann C, Block C, Haas K, Weber C, Geisen C, Winde G, Möröy T, Müller O: Sulindac sulfide inhibits Ras signaling. Oncogene 17: 1769-1776 (1998). doi.org/10.1038/sj.onc.1202085

Deka J, Kuhlmann J, Müller O: A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau. The FEBS Journal 253: 591-597 (1998). doi.org/10.1046/j.1432-1327.1998.2530591.x

Müller O, Nimmrich I, Finke U, Friedl W, Hoffmann I: A beta-catenin mutation in a sporadic colorectal tumor of the RER phenotype and absence of beta-catenin germline mutations in FAP patients. Genes Chromosomes and Cancer 22: 37-41 (1998)

Deuter R, Müller O: Detection of APC mutations in stool DNA of patients with colorectal cancer by HD-PCR. Human Mutation 11: 84-89 (1998). doi.org/10.1002/(sici)1098-1004(1998)11:1%3C84::aid-humu13%3E3.0.co;2-v

Jenne DE, Reimann H, Nezu JI, Friedl W, Loff S, Jeschke R, Müller O, Back W, Zimmer M: Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nature Genetics 18: 38-44 (1998). doi.org/10.1038/ng0198-38

1997-1990

Nimmrich I, Friedl W, Kruse R, Pietsch S, Hentsch S, Deuter R, Winde G, Müller O: Loss of the PLA2G2A gene in a sporadic colorectal tumor of a patient with a PLA2G2A germline mutation and absence of PLA2G2A germline alterations in patients with FAP. Human Genetics 100: 345-349 (1997). doi.org/10.1007/s004390050514

Winde G, Schmid KW, Brandt B, Müller O, Osswald H: Clinical and genomic influence of sulindac on rectal mucosa in familial adenomatous polyposis. Diseases of the Colon & Rectum 40: 1156-1169 (1997). doi.org/10.1007/bf02055161

Hirschl D, Bayer P, Müller O: Secondary structure of an armadillo single repeat from the APC protein. FEBS Letters 383: 31-36 (1996) und FEBS Letters 383: Cover Picture. doi.org/10.1016/0014-5793(96)00215-3

Deuter R, Linz J, Pietsch S, Winde G, Hentsch S, Müller O: DNA alterations in sporadic colorectal tumors do not correlate with tumor staging diagnosed by the TNM system. Cancer Letters 109: 161-169 (1996). doi.org/10.1016/s0304-3835(96)04441-2

Deuter R, Pietsch S, Hertel S, Müller O: A method for preparation of fecal DNA for PCR. Nucleic Acids Research 23: 3800-3801 (1995). doi.org/10.1093/nar/23.18.3800

Munemitsu S, Souza B, Müller O, Albert I, Rubinfeld B, Polakis P: The APC gene product associates with microtubules in vivo and catalyses their assembly in vitro. Cancer Research 54: 3676-3681 (1994)

Rubinfeld B, Souza B, Albert I, Müller O, Chamberlain S, Masiarz F, Munemitsu S, Polakis P: Association of the APC gene product with beta-Catenin. Science 262: 1731-1734 (1993). doi.org/10.1126/science.8259518

Wong G, Müller O, Clark R, Conroy L, Moran MF, Polakis P, McCormick F: Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62. Cell 69: 551-558 (1992) und Cell 69: Cover Picture. doi.org/10.1016/0092-8674(92)90455-l

Bauer-Hofmann R, Klimek F, Buchmann A, Müller O, Bannasch P, Schwarz M: Role of mutations at codon 61 of the c-Ha-ras gene during diethylnitrosamine-induced hepatocarcinogenesis in C3H/He mice. Molecular Carcinogenesis 6: 60-67 (1992). doi.org/10.1002/mc.2940060110

Müller O, Kress S, Schwarz M: Absence of mutations in the functional parts of the p120-GAP gene in carcinogen-induced mouse liver tumors. Carcinogenesis 13: 1903-1905 (1992). doi.org/10.1093/carcin/13.10.1903

Müller O, Frech M, Gideon P, Wittinghofer A, Schwarz M: Differences in GAP (GTPase activating protein) activity between liver tumors and normal liver tissue in mice. Oncogene 7: 1407-1412 (1992)

Müller O, Alonso A, Buchmann A, Bauer-Hofmann R, Bock KW, Schwarz M: Detection of genomic alterations in carcinogen-induced mouse liver tumors by DNA fingerprint analysis. Molecular Carcinogenesis 3: 330-334 (1990). doi.org/10.1002/mc.2940030604

Patente

1.) Müller O, Deuter R: Process for purifying, stabilising or isolating nucleic acids from biological materials
Patent PCT / EP 96 / 03595 (1998)

2.) Müller O, Sprenger-Haußels M, Bastian H, Vollert S: A method for purification of DNA from biological materials
Patent PCT / EP 98 / 00052 (2000)

3.) Müller O: The interaction of the APC wild-type tumor suppressor protein with DNA and its high nuclear level in proliferating cells as new tools in research and diagnostics – a new method for the detection of fast proliferating cells
Patent PCT / EP 00 / 06656 (2000)

4.) Böse G, Plaß M, Kuhlmann J, Müller O: An assay for the detection of primary DNA lesions based on the interaction of the DNA with DNA repair proteins
Patent PCT / EP 01 / 06591 (2001)

5.) Kahmann S, Müller O: A new method for detecting DNA mutations
Anmeldung 01 07 317 beim Deutschen Patentamt (2001)

6.) Karaguni M, Glüsenkamp KH, Winde G, Möröy T, Müller O: Novel Indenyl derivatives with therapeutic implications
Anmeldung 01 19 483 beim Deutschen Patentamt (2001)

7.) Karaguni M, Herter P, Gourzoulidou E, Carpintero M, Waldmann H, Müller O: Novel compounds, derived from Sulindac as a lead compound, with anti-proliferative, apoptosis inducing or cell transformation reverting effects, and cell biological assays for measuring these effects
Anmeldung 01 63 426 beim Deutschen Patentamt (2001)

8.) Sievers S, Müller O: Method for the analysis of nucleic acid methylation
Patent PCT / EP 06 / 009233 (2006)

9.) Müller O: A child-safe device for reversible fixation of standard blisters
Utility Patent (Gebrauchsmuster) 06 003 379 beim Deutschen Patentamt (2006)

10.) Müller O: A card set for easy learning of complex graphics and structures
Utility Patent (Gebrauchsmuster) 09 016 961 beim Deutschen Patentamt (2009)

11.) Apfel J, Reischmann P, Müller O: Ein neuer Vektor und Protokolle zur Anreicherung und zur Analyse von Zellen mit aktiviertem Wnt-Signalweg
Utility Patent (Gebrauchsmuster) IPC C12N 15/79 beim Deutschen Patentamt (2013)


 

Übersichtsartikel (Reviews), Buchkapitel, Bücher, Internetseiten

1.) Böse G, Deka J, Herter P, Müller O, Nimmrich I: Die Krebsentstehung auf molekularer Ebene
Jahrbuch der Max-Planck-Gesellschaft: 286-290 (1997)

2.) Müller O: Methoden zur Isolierung und zur Analyse von DNA aus fäkalen Proben als Grundlage einer nicht-invasiven molekulargenetischen Tumor- und Infektionsdiagnostik.
Jahrbuch des Wissenschaftszentrums Nordrhein-Westfalen: 127-139 (1999)

3.) Müller O: Die Analyse von DNA aus fäkalen Proben als Grundlage einer nicht invasiven molekularen Diagnose gastrointestinaler Tumoren
Fortschritt und Fortbildung in der Medizin, Band 25, S. 151-157, Bundesärztekammer, Köln (Hrsg.) Deutscher Ärzte-Verlag (2001)

4.) Müller O, Wittinghofer A: Ras binding compounds
Tumor Suppressing Viruses, Genes and Drugs – Innovative Cancer Therapy Approaches by Hiroshi Maruta (Editor), Academic Press New York, Chapter 15, 311-327 (2002)

5.) Chtarbova S, Müller O: Eine Frage zum Thema Krebs? Die Antwort weiß ganz allein der Wnt Signalweg
BioSpektrum 6: 701-703 (2003)

6.) Müller O: Identification of colon cancer patients by molecular diagnosis
Digestive Diseases 21(4): 315-319 (2003). DOI: 10.1159/000075354

7.) Linke C, Müller O: Colorectal Cancer Screening: Molecular Diagnosis
Encyclopedia of Medical Genomics and Proteomics by Jürgen Fuchs & Maurizio Podda (Editors), Taylor & Francis Books New York 1(1): 1-5 (2007)

8.) Röhrs S, Müller O: The Wnt pathway as a target for novel anti-cancer drugs
Current Chemical Biology 1: 227-239 (2007)

9.) Hauss O, Müller O: The Protein Truncation Test (PTT) in mutation detection and molecular diagnosis
Methods in Molecular Biology: In vitro Transcription and Translation Protocols, Second Edition by Guido Grandi (Editor), Humana Press Totowa 375: 151-164 (2007). DOI: 10.1007/978-1-59745-388-2_8

10.) Vlad A, Röhrs S, Klein-Hitpass L, Müller O: The first five years of the Wnt targetome
Cellular Signalling, 20(5): 795-802 (2008). DOI: 10.1016/j.cellsig.2007.10.031

11.) Wagener C, Müller O: Molekulare Onkologie: Entstehung, Progression, klinische Aspekte
Lehrbuch, 3. Auflage, Georg Thieme Verlag Stuttgart (2009). ISBN: 978-3-13-103513-4

12.) Wagener C, Müller O: www.onkoview.com
Internet-Seite zum Lehrbuch „Molekulare Onkologie“ (2009)

13.) Wagener C, Müller O: www.youtube.com/Onkoview
Internet-Seite mit Animationen zur Molekularen Onkologie (2010)

14.) Apfel J, Parikh JR, Reischmann P, Ewing RM, Müller O, Xia Y, Dominguez, I: The Wnt pathway in Cancer.
Systems Biology of Cancer by Sam Thiagalingam (Editor) (2016). DOI: 10.4236/jbm.2016.412017

15.) Wagener C, Stocking C, Müller O: Cancer Signaling: From Molecular Biology to Targeted Therapy
Lehrbuch, Wiley-VCH (2016) ISBN:9783527336586