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Veröffentlichungen

2019 - 2015


W. Hahnel, K. Schulte, M. Hafner, O. Müller, Extraction of DNA from Difficult Samples with an Automatable Portable System INTRODUCTION, IJPPR. 12 (2018) 238–250.

W. Hahnel, K. Schulte, O. Müller, Extraction of DNA from difficult samples with an automated portable system, in: Int. Conf. OnGenetics Mol. Res., Dubai, 2017: p. 2. https://doi.org/10.29011/2574-7371-C1-003.

W. Hahnel, K. Schulte, O. Muller, Development of an automated portable system for extraction of DNA from difficult samples, in: 13th Biotechnol. Congr., 2016: pp. 6–8. doi.org/10.4172/2155-952X.C1.068.

R. Di Liddo, T. Bertalot, A. Schuster, S. Schrenk, O. Müller, J. Apfel, P. Reischmann, S. Rajendran, R. Sfriso, M. Gasparella, P.P. Parnigotto, M.T. Conconi, K.H. Schäfer, Fluorescence-based gene reporter plasmid to track canonical Wnt signaling in ENS inflammation, Am. J. Physiol. Liver Physiol. 310 (2016) G337–G346. doi.org/10.1152/ajpgi.00191.2015.

A. Vlad-Fiegen, N. Freytag, S. Dorn, O. Mueller, S. Eberth née Röhrs, The Wnt Pathway Target Gene CCND1 Changes Mitochondrial Localization and Decreases Mitochondrial Activity in Colorectal Cancer Cell Line SW480, J. Biosci. Med. 04 (2016) 132–143. doi.org/10.4236/jbm.2016.412017.

P. Reischmann, J. Fiebeck, N. Weiden, O. Müller, Measured Effects of Wnt3a on Proliferation of HEK293T Cells Depend on the Applied Assay, Int. J. Cell Biol. 2015 (2015) 1–8. doi.org/10.1155/2015/928502.

J. Apfel, J.R. Parikh, P. Reischmann, R.M. Ewing, O. Müller, Y. Xia, I. Dominguez, The Wnt signaling network in cancer, in: S. Thiagalingam (Ed.), Syst. Biol. Cancer, Cambridge University Press, 2015: pp. 222–255. doi.org/10.1017/CBO9780511979811.016.

2014-2010


Götze S, Coersmeyer M, Müller O, Sievers S: Histone acetylase inhibitors induce attenuation of Wnt signaling and TCF7L2 depletion in colorectal carcinoma cells. International Journal of Oncology 45(4), 1715-1723 (2014). www.spandidos-publications.com/10.3892/ijo.2014.2550

Balke D, Zieten I, Strahl A, Müller O, Müller S: Design and characterization of a twin ribozyme for the repair of a deletion mutation within the oncogenic CTNNB1-DS45-mRNA. ChemMedChem 9(9), 2128-2137 (2014). doi.org/10.1002/cmdc.201402166

Apfel J, Reischmann P, Müller O: A new fluorescence-based reporter gene vector as a atool for analyzing and fishing cells with activated Wnt signaling pathway. ISRN Oncology Article ID 603129 (2013). doi.org/10.1155/2013/603129

Vlad-Fiegen A, Langerak A, Eberth S, Müller O: The Wnt pathway destabilizes adherens junctions and promotes cell migration via b-catenin and its target gene cyclin D1. FEBS Open Bio 2, 26-31 (2012). doi.org/10.1016/j.fob.2012.02.004

Drude I, Strahl A, Galla D, Müller O, Müller S: Design of hairpin ribozyme variants with improved activity for poorly processed substrates. The FEBS Journal: 278, 622-633 (2011). doi.org/10.1111/j.1742-4658.2010.07983.x

Götze S, Wolter M, Reifenberger G, Müller O, Sievers S: Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas. International Journal of Cancer 126, 2584-2593 (2010). doi.org/10.1002/ijc.24981

Lanckohr C, Debiec-Richter M, Müller O, Homann H, Lehnhardt M, Herter P, Kuhnen C: Gardner fibroma: Case report with morphologic, molecular biological and genetic analysis and discussion of a relatively new soft tissue tumor entity. Der Pathologe 1, 1-9 (2010). doi.org/10.1007/s00292-009-1260-y

2009-2008


Götze S, Feldhaus V, Traska T, Wolter M, Reifenberger G, Tannapfel A, Kuhnen C, Martin D, Müller O, Sievers S: ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma. BMC Cancer 9, 447 (2009). doi.org/10.1186/1471-2407-9-447

Marelli MM, Moretti RM, Mai S, Müller O, van Groeninghen J, Limonta P: Novel insights into GnRH receptor activity: Role in the control of human glioblastoma cell proliferation. Oncology reports 21: 1277-1282 (2009). doi.org/10.3892/or_00000351

Röhrs S, Kutzner N, Vlad A, Grunwald T, Ziegler S, Müller O: Chronological expression of Wnt target genes Ccnd1, Myc, Cdkn1a, Tfrc, Plf1 and Ramp3. Cell Biology International 33: 501-508 (2009). dx.doi.org/10.1016/j.cellbi.2009.01.016

Daigeler A, Klein-Hitpass L, Stricker I, Müller O, Kuhnen C, Chromik AM, Steinstraesser L, Goertz O, Steinau HU, Lehnhardt M: Malignant fibrous histiocytoma – pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study. Langenbeck’s Archives of Surgery 394(3): 261-275 (2009). doi.org/10.1007/s00423-009-0465-0

Tickenbrock L, Hehn S, Sargin B, Choudhary C, Bäumer N, Bürger H, Schulte B, Müller O, Berdel WE, Müller-Tidow C, Serve H: Activation of Wnt signalling in acute leukaemia by induction of Frizzled-4. International Journal of Oncology 33(6): 1215-1221 (2008). dx.doi.org/10.3892/ijo_00000111

Daigeler A, Lehnhardt M, Müller O, Steinau HU, Homann H, Hauser J, Chromik A, Klein-Hitpass L: Heterogeneous in vitro effects of doxorubicin on gene expression in primary human liposarcoma cultures. BMC Cancer 8: 313 (2008). dx.doi.org/10.1186%2F1471-2407-8-313

Sievers S, Fritzsch C, Kuhnen C, Müller O: SPMSP: Solid-phase PCR with colorimetric read-out for quantitative methylation analysis. Anticancer Research 28: 2055-2060 (2008).

Csepregi A, Röcken C, Hoffmann J, Ping G, Saliger S, Müller O, Schneider-Stock R, Kutzner N, Roessner A, Malfertheiner P, Ebert MP: APC promoter methylation and protein expression in hepatocellular carcinoma. Journal of Cancer Research and Clinical Oncology 134(5): 579-589 (2008). doi.org/10.1007/s00432-007-0321-y

Wehner F, Nören-Müller A, Müller O, Reis-Correa I, Giannis A, Waldmann H: Indoloquinolizidine Derivatives as Novel and Potent Apoptosis Inducers and Cell-Cycle Blockers. ChemBioChem 9: 401-405 (2008). ChemBioChem 9: Cover Picture. doi.org/10.1002/cbic.200700558

2007-2006


Köster MP, Müller O, Pollerberg E: Adenomatous Polyposis Coli (APC) is differentially distributed in growth cones and modulates their local stability and steering. Journal of Neuroscience 27(46): 12590-12600 (2007). doi.org/10.1523/jneurosci.2250-07.2007

Fürstner A, Nevado C, Wasser M, Tremblay M, Chevrier C, Teply F, Aïssa C, Moulin E, Müller O: Total synthesis of Iejimalide A-D and assessment of the remarkable actin-depolymerizing capacity of these polyene macrolides. Journal of the American Chemical Society 129(29): 9150-9161 (2007). doi.org/10.1021/ja072334v

Lessmann T, Leuenberger MG, Menninger S, Lopez-Canet M, Müller O, Hümmer S, Bormann J, Korn K, Fava E, Zerial M, Mayer TU, Waldmann H: Natural Product-derived Modulators of Cell Cycle Progression and Viral Entry by Enantioselective Oxa Diels-Alder Reactions on the Solid Phase. Chemistry & Biology 14(4): 443-451 (2007). dx.doi.org/10.1016/j.chembiol.2007.02.008

Fürstner A, Nagano T, Müller C, Seidel G, Müller O: Total synthesis and evaluation of the actin-binding properties of microcarpalide and a focused library of analogues. Chemistry 13: 1452-1462 (2007). doi.org/10.1002/chem.200601370

Ziegler S, Röhrs S, Tickenbrock L, Langerak A, Chud S, Feldmann I, Jakubowski N, Müller O: 24p3 is regulated by the Wnt pathway independently from iron. Cancer Genetics and Cytogenetics 174: 16-23 (2007). dx.doi.org/10.1016/j.cancergencyto.2006.11.004

Fürstner A, Kirk D, Fenster MDB, Aïssa C, De Souza D, Nevado C, Tuttle T, Thiel W, Müller O: Latrunculin Analogues with Improved Biological Profiles by Diverted Total Synthesis: Preparation, Evaluation and Computational Analysis. Chemistry 13: 135-140 (2007). doi.org/10.1002/chem.200601136

Sievers S, Fritzsch C, Kutzner N, Lehnhardt M, Kuhnen C, Müller O: Hypermethylation of the APC Promoter but lack of APC mutations in Myxoid/Round-cell Liposarcoma. International Journal of Cancer 119: 2347-2352 (2006). doi.org/10.1002/ijc.22117

Shahmoradgoli M, Müller O, Kutzner, N, Noorinayer B, Zali MR: Gene Symbol: APC. Disease: Familial adenomatous polyposis coli. Human Genetics 118(6): 776 (2006)

Sievers S, Fritzsch C, Grzegorczyk M, Kuhnen C, Müller O: Absolute beta-catenin concentrations in Wnt pathway stimulated and non-stimulated cells. Biomarkers 11 (3): 270-278 (2006). doi.org/10.1080/13547500600633954

2005


Lumbierres M, Palomo JM, Kragol G, Röhrs S, Müller O, Waldmann H: Solid-Phase Synthesis of Lipidated Peptides. Chemistry 11: 7405-7415 (2005). doi.org/10.1002/chem.200500476

Becker CFW, Wacker R, Bouschen W, Seidel R, Kolaric B, Lang P, Schroeder H, Müller O, Niemeyer CM, Spengler B, Goody RS, Engelhard M: Protein-DNA Arrays as Tools for Detection of Protein-Protein Interactions by Mass Spectrometry. Angewandte Chemie 117: 7808-7812 (2005). Angewandte Chemie Int Edit 44: 7635-7639 (2005). doi.org/10.1002/cbic.201200597

Barun O, Kumar K, Sommer S, Langerak A, Mayer TU, Müller O, Waldmann H: Natural Product Guided Synthesis of a Spiroacetal Collection Reveals Modulators of Tubulin Cytoskeleton Integrity. European Journal of Organic Chemistry 22: 4773-4788 (2005). European Journal of Organic Chemistry 22 (2005): Cover Picture. doi.org/10.1002/ejoc.200500605

Lehnhardt M, Klein-Hitpass L, Kuhnen C, Homann HH, Daigeler A, Steinau HU, Röhrs S, Schnorr L, Steinstraesser L, Müller O: Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BioMedCentral Cancer 5: 74-90 (2005). doi.org/10.1186/1471-2407-5-74

Fürstner A, Kirk D, Fenster M, Aissa C, De Souza D, Müller O: Diverted Total Synthesis: Preparation of a Focused Library of Latrunculin Analogues and Evaluation of their Actin-Binding Properties. Proceedings of the National Academy of Science of the USA (PNAS) 102(23): 8103-8108 (2005). doi.org/10.1073/pnas.0501441102

Lehnhardt M, Muehlberger T, Kuhnen C, Brett D, Steinau HU, Joneidi Jafari H, Steinstraesser L, Müller O, Homann HH: Feasibility of Chemosensitivity Testing in Soft Tissue Sarcomas. World Journal of Surgical Oncology 3(20): 1-12 (2005). dx.doi.org/10.1186%2F1477-7819-3-20

Ziegler S, Röhrs S, Tickenbrock L, Möröy T, Klein-Hitpass L, Vetter IR, Müller O: Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation. The FEBS Journal 272(7): 1600-1615 (2005). doi.org/10.1111/j.1742-4658.2005.04581.x

Rosenbaum C, Röhrs S, Müller O, Waldmann H: Modulation of MRP-1-Mediated Multidrug Resistance by Indomethacin Analogues. Journal of Medicinal Chemistry 48(4): 1179-1187 (2005). doi.org/10.1021/jm0499099

Kutzner N, Hoffmann I, Linke C, Thienel T, Grzegorczyk M, Urfer W, Martin D, Winde G, Traska T, Hohlbach G, Müller KM, Kuhnen C, Müller O: Non-invasive colorectal cancer diagnosis by the combined application of molecular diagnosis and the faecal occult blood test. Cancer Letters 229: 33-41 (2005)

Chen J, Röcken C, Lofton-Day C, Schulz HU, Müller O, Kutzner N, Malfertheiner P, Ebert M: Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis. Carcinogenesis 26(1): 37-43 (2005). doi.org/10.1093/carcin/bgh280

2004-2003


Karaguni IM, Gourzoulidou E, Carpintero M, Langerak A, Klein-Hitpaß L, Möröy T, Winde G, Waldmann H, Müller O: SMAF-1 inhibits the APC/b-catenin pathway and shows properties similar to these of the tumor suppressor protein APC. ChemBioChem 5(9): 1267-1270 (2004). doi.org/10.1002/cbic.200400078

Waldmann H, Karaguni IM, Carpintero M, Gourzoulidou E, Herrmann C, Brockmann C, Oschkinat H, Müller O: Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway. Angewandte Chemie 116(4): 460-464 (2004). Angewandte Chemie Int Edit 43(4): 454-458 (2004). doi.org/10.1002/anie.200353089

Müller O, Gourzoulidou E, Carpintero M, Karaguni IM, Langerak A, Herrmann C, Möröy T, Klein-Hitpaß L, Waldmann H: Identification of potent Ras signaling inhibitors by Pathway-Selective Phenotype-Based Screening. Angewandte Chemie116(4): 456-460 (2004). Angewandte Chemie Int Edit 43(4): 450-454 (2004). doi.org/10.1002/anie.200352587

Rosenbaum C, Baumhof P, Mazitschek R, Müller O, Giannis A, Waldmann H: Synthesis and biological evaluation of an Indomethacin library reveals a new class of angiogenesis-related kinase inhibitors. Angewandte Chemie 116(3): 226-230 (2004). Angewandte Chemie Int Edit 43(2): 224-228 (2004). doi.org/10.1002/anie.200352582

Oliveira MJ, van Damme J, Lauwaet T, de Corte V, Bruyne G, Verschraegen G, Vaneechoutte M, Goethals M, Ahmadian MR, Müller O, Vandekerckhove J, Mareel M, Leroy A: b-Casein-derived Peptides, produced by bacteria, stimulate cancer cell invasion and motility. EMBO Journal 22(22): 6161-6173 (2003). doi.org/10.1093/emboj/cdg586

Thutewohl M, Kissau L, Popkirova B, Karaguni IM, Nowak T, Bate M, Kuhlmann J, Müller O, Waldmann H: Identification of mono- and bisubstrate inhibitors of protein farnesyltransferase and inducers of apoptosis from a pepticinnamin E library. Bioorganic & Medicinal Chemistry 11: 2617-2626 (2003). doi.org/10.1016/s0968-0896(03)00160-3

Andreyev HJN, Benamouzig R, Beranek M, Clarke P, Cunningham D, Norman AR, Giaretti W, de Goeij AFPM, Iacopetta BJ, Jullian E, Krtolica K, Lee JQ, Wang ST, Lees N, Al-Mulla F, Müller O, Pauly M, Pricolo V, Russo A, Troungos C, Urosevic N, Ward R: Mutant K-ras2 in serum. Gut 52(6): 915-916 (2003). doi.org/10.1136/gut.52.6.915-a

Ebert MPA, Yu J, Hoffmann J, Rocco A, Röcken C, Kahmann S, Müller O, Korc M, Sung JJ, Malfertheiner P: Loss of b-catenin expression in metastatic gastric cancer. Journal of Clinical Oncology 21(9): 1708-1714 (2003). dx.doi.org/10.1200/JCO.2003.10.017

Tickenbrock L, Kößmeier K, Rehmann H, Herrmann C, Müller O: Differences between the interaction of b-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acids repeats of the APC protein. Journal of Molecular Biology 327: 359-367 (2003). doi.org/10.1016/S0022-2836(03)00144-X

2002


Tickenbrock L, Cramer J, Vetter I, Müller O: Structure of the aminoterminal nuclear export domain of the APC tumor suppressor protein. Annals of the New York Academy of Science 973: 109-111 (2002). dx.doi.org/10.1111/j.1749-6632.2002.tb04616.x

Brohm D, Philippe N, Metzger S, Bhargava A, Müller O, Lieb F, Waldmann H: Solid-Phase synthesis of dysidiolide-derived protein phosphatase inhibitors. Journal of the American Chemical Society 124(44): 13171-13178 (2002). doi.org/10.1021/ja027609f

Debruyne P, Bruyneel E, Karaguni IM, Li X, Flatau G, Müller O, Zimber A, Gespach C, Mareel M: Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of multiple oncogenic signalling pathways. Oncogene 21(44):6740-6750 (2002). doi.org/10.1038/sj.onc.1205729

Thutewohl M, Kissau LA, Popkirova B, Karaguni I-M, Nowak T, Bate M, Kuhlmann J, Müller O, Waldmann H: Solid-phase synthesis and biological evaluation of a Pepticinnamine E library. Angewandte Chemie 114(19): 3768-3772 (2002). Angewandte Chemie Int Edit 41(19): 3616-3620 (2002).

Chtarbova S, Nimmrich I, Erdmann S, Herter P, Remmer M, Kitajewski J, Müller O: Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation. Biochemical Journal 367: 723-728 (2002). doi.org/10.1042/bj20020699

Tickenbrock L, Cramer J, Vetter I, Müller O: The coiled-coil region (amino acids 129-250) of the tumor suppressor protein Adenomatous Polyposis coli (APC). Its structure and interaction with chromosome maintenance region 1 (crm-1). Journal of Biological Chemistry 277: 32332-32338 (2002). doi.org/10.1074/jbc.M203990200

Karaguni IM, Herter P, Debruyne P, Chtarbova S, Kasprzynski A, Herbrand U, Ahmadian MR, Glüsenkamp KH, Winde G, Mareel M, Möröy T, Müller O: The new Sulindac derivative IND 12 reverses Ras-induced cell transformation. Cancer Research 62: 1718-1723 (2002).

Karaguni IM, Glüsenkamp KH, Langerak A, Geisen C, Ullrich V, Winde G, Möröy T, Müller O: New indene-derivatives with anti-proliferative properties. Bioorganic & Medicinal Chemistry Letters 12: 709-713 (2002). doi.org/10.1016/s0960-894x(01)00839-3

Brohm D, Metzger S, Bhargava A, Müller O, Lieb F, Waldmann H: Natural Products are Biologically Validated Starting Points in Structural Space for Compound Library Development: Solid Phase Synthesis of Dysidiolide-Derived Phosphatase Inhibitors. Angewandte Chemie 114(2): 319-323 (2002). Angewandte Chemie Int Edit 41(2): 307-311 (2002). Angewandte Chemie International Edition 41(2): Cover Picture (prämiert als Titelblatt des Jahres). doi.org/10.1002/1521-3773(20020118)41:2%3C307::aid-anie307%3E3.0.co;2-1

Kahmann S, Herter P, Kuhnen C, Müller KM, Muhr G, Martin D, Soddemann M, Müller O: A non-radioactive protein truncation test for sensitive detection of all stop and frameshift mutations. Human Mutation 19(2): 165-172 (2002). dx.doi.org/10.1002/humu.10024

Ebert MPA, Fei G, Kahmann S, Müller O, Yu J, Sung JJ, Malfertheiner P: Increased b-catenin mRNA levels and mutational alterations of the APC and b-catenin gene are present in intestinal-type gastric cancer. Carcinogenesis 23(1): 87-91 (2002). doi.org/10.1093/carcin/23.1.87

2001-2000


Andreyev HJ, Norman AR, Cunningham D, Oates J, Dix BR, Iacopetta BJ, Young J, Walsh T, Ward R, Hawkins N, Beranek M, Jandik P, Benamouzig R, Jullian E, Laurent-Puig P, Olschwang S, Müller O, et al.: Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. British Journal of Cancer 85(5): 692-696 (2001). doi.org/10.1054/bjoc.2001.1964

Leroy K, Duyckaerts C, Bovekamp L, Müller O, Anderton BH, Brion JP: Increase of Adenomatous Polyposis coli immunoreactivity is a marker of reactive astrocytes in Alzheimer’s disease and in other pathological conditions. Acta Neuropathologica 102: 1-10 (2001). dx.doi.org/10.1007/s004010000340

Nimmrich I, Erdmann S, Melchers U, Chtarbova S, Finke U, Hentsch S, Hoffmann I, Oertel M, Hoffmann W, Müller O: The novel ependymin related gene UCC1 is highly expressed in colorectal tumor cells. Cancer Letters 165: 71-79 (2001). doi.org/10.1016/s0304-3835(01)00390-1

Böse G, Kuhlmann J, Plass M, Müller O: Microplate ELISA assay for the detection of primary DNA alterations based on the interaction with UvrA/UvrB. Analytical Biochemistry 292: 1-7 (2001). doi.org/10.1006/abio.2001.5054

Nimmrich I, Erdmann S, Melchers U, Finke U, Hentsch S, Moyer MP, Hoffmann I, Müller O: Seven genes that are differentially transcribed in colorectal tumor and normal cell lines. Cancer Letters 160: 37-43 (2000). dx.doi.org/10.1016/S0304-3835(00)00553-X

Kuhnen C, Herter P, Müller O, Muehlberger T, Krause L, Homann H, Steinau HU, Müller KM: beta-catenin in soft tissue sarcomas: expression is related to proliferative activity in high-grade sarcomas.Modern Pathology 13(9): 1005-1013 (2000). doi.org/10.1038/modpathol.3880181

Erdmann KS, Kuhlmann J, Lessmann V, Herrmann L, Eulenburg V, Müller O, Heumann R: The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain. Oncogene 19: 3894-3901 (2000). doi.org/10.1038/sj.onc.1203725

Kuhnen C, Herter P, Monse H, Kahmann S, Muehlberger T, Vogt PM, Steinau HU, Müller KM, Müller O: APC and beta-catenin in alveolar soft part sarcoma (ASPS) – Immunohistochemical and molecular genetic analysis. Pathology Research and Practice 196: 299-304 (2000). doi.org/10.1016/s0344-0338(00)80059-x

1999-1998


Deka J, Herter P, Sprenger-Haußels M, Koosch S, Franz D, Müller KM, Kuhnen C, Hoffmann I, Müller O: The APC protein binds to A/T rich DNA sequences. Oncogene 18: 5654-5661 (1999). doi.org/10.1038/sj.onc.1202944

Herter P, Kuhnen C, Müller KM, Wittinghofer A, Müller O: Intracellular distribution of beta-catenin in colorectal adenomas, carcinomas and Peutz-Jeghers polyps. Journal of Cancer Research and Clinical Oncology 125: 297-304 (1999). doi.org/10.1007/s004320050277

Winde G, Lügering N, Glodny B, Schmid KW, Müller O, Senninger N, Osswald H: Decreased Her-2 tyrosine kinase expression in rectal mucosa of FAP patients following low-dose sulindac chemoprevention. Cancer Letters 134: 201-207 (1998). doi.org/10.1016/s0304-3835(98)00254-7

Kuhnen C, Herter P, Steinau H, Müller O, Müller KM: Intracellular distribution of beta-Catenin in soft tissue tumors. Verhandlungen der deutschen Gesellschaft für Pathologie 82: 322-326 (1998)

Hermann C, Block C, Haas K, Weber C, Geisen C, Winde G, Möröy T, Müller O: Sulindac sulfide inhibits Ras signaling. Oncogene 17: 1769-1776 (1998). doi.org/10.1038/sj.onc.1202085

Deka J, Kuhlmann J, Müller O: A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau. The FEBS Journal 253: 591-597 (1998). doi.org/10.1046/j.1432-1327.1998.2530591.x

Müller O, Nimmrich I, Finke U, Friedl W, Hoffmann I: A beta-catenin mutation in a sporadic colorectal tumor of the RER phenotype and absence of beta-catenin germline mutations in FAP patients. Genes Chromosomes and Cancer 22: 37-41 (1998)

Deuter R, Müller O: Detection of APC mutations in stool DNA of patients with colorectal cancer by HD-PCR. Human Mutation 11: 84-89 (1998). doi.org/10.1002/(sici)1098-1004(1998)11:1%3C84::aid-humu13%3E3.0.co;2-v

Jenne DE, Reimann H, Nezu JI, Friedl W, Loff S, Jeschke R, Müller O, Back W, Zimmer M: Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nature Genetics 18: 38-44 (1998). doi.org/10.1038/ng0198-38

1997-1990


Nimmrich I, Friedl W, Kruse R, Pietsch S, Hentsch S, Deuter R, Winde G, Müller O: Loss of the PLA2G2A gene in a sporadic colorectal tumor of a patient with a PLA2G2A germline mutation and absence of PLA2G2A germline alterations in patients with FAP. Human Genetics 100: 345-349 (1997). doi.org/10.1007/s004390050514

Winde G, Schmid KW, Brandt B, Müller O, Osswald H: Clinical and genomic influence of sulindac on rectal mucosa in familial adenomatous polyposis. Diseases of the Colon & Rectum 40: 1156-1169 (1997). doi.org/10.1007/bf02055161

Hirschl D, Bayer P, Müller O: Secondary structure of an armadillo single repeat from the APC protein. FEBS Letters 383: 31-36 (1996) und FEBS Letters 383: Cover Picture. doi.org/10.1016/0014-5793(96)00215-3

Deuter R, Linz J, Pietsch S, Winde G, Hentsch S, Müller O: DNA alterations in sporadic colorectal tumors do not correlate with tumor staging diagnosed by the TNM system. Cancer Letters 109: 161-169 (1996). doi.org/10.1016/s0304-3835(96)04441-2

Deuter R, Pietsch S, Hertel S, Müller O: A method for preparation of fecal DNA for PCR. Nucleic Acids Research 23: 3800-3801 (1995). doi.org/10.1093/nar/23.18.3800

Munemitsu S, Souza B, Müller O, Albert I, Rubinfeld B, Polakis P: The APC gene product associates with microtubules in vivo and catalyses their assembly in vitro. Cancer Research 54: 3676-3681 (1994)

Rubinfeld B, Souza B, Albert I, Müller O, Chamberlain S, Masiarz F, Munemitsu S, Polakis P: Association of the APC gene product with beta-Catenin. Science 262: 1731-1734 (1993). doi.org/10.1126/science.8259518

Wong G, Müller O, Clark R, Conroy L, Moran MF, Polakis P, McCormick F: Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62. Cell 69: 551-558 (1992) und Cell 69: Cover Picture. doi.org/10.1016/0092-8674(92)90455-l

Bauer-Hofmann R, Klimek F, Buchmann A, Müller O, Bannasch P, Schwarz M: Role of mutations at codon 61 of the c-Ha-ras gene during diethylnitrosamine-induced hepatocarcinogenesis in C3H/He mice. Molecular Carcinogenesis 6: 60-67 (1992). doi.org/10.1002/mc.2940060110

Müller O, Kress S, Schwarz M: Absence of mutations in the functional parts of the p120-GAP gene in carcinogen-induced mouse liver tumors. Carcinogenesis 13: 1903-1905 (1992). doi.org/10.1093/carcin/13.10.1903

Müller O, Frech M, Gideon P, Wittinghofer A, Schwarz M: Differences in GAP (GTPase activating protein) activity between liver tumors and normal liver tissue in mice. Oncogene 7: 1407-1412 (1992)

Müller O, Alonso A, Buchmann A, Bauer-Hofmann R, Bock KW, Schwarz M: Detection of genomic alterations in carcinogen-induced mouse liver tumors by DNA fingerprint analysis. Molecular Carcinogenesis 3: 330-334 (1990). doi.org/10.1002/mc.2940030604

Patente


Hahnel und Müller: Automatisierbares portables System zur Extraktion von DNA aus schwierigen Proben. Utility Patent 20 2018 001 670 (IPC: C12N 15/10), eingetragen am 24.05.2018

Apfel J, Reischmann P, Müller O: Ein neuer Vektor und Protokolle zur Anreicherung und zur Analyse von Zellen mit aktiviertem Wnt-Signalweg
Utility Patent (Gebrauchsmuster) IPC C12N 15/79 beim Deutschen Patentamt (2013)

Müller O: A card set for easy learning of complex graphics and structures
Utility Patent (Gebrauchsmuster) 09 016 961 beim Deutschen Patentamt (2009)

Müller O: A child-safe device for reversible fixation of standard blisters
Utility Patent (Gebrauchsmuster) 06 003 379 beim Deutschen Patentamt (2006)

Sievers S, Müller O: Method for the analysis of nucleic acid methylation
Patent PCT / EP 06 / 009233 (2006)

Karaguni M, Herter P, Gourzoulidou E, Carpintero M, Waldmann H, Müller O: Novel compounds, derived from Sulindac as a lead compound, with anti-proliferative, apoptosis inducing or cell transformation reverting effects, and cell biological assays for measuring these effects
Anmeldung 01 63 426 beim Deutschen Patentamt (2001)

Karaguni M, Glüsenkamp KH, Winde G, Möröy T, Müller O: Novel Indenyl derivatives with therapeutic implications
Anmeldung 01 19 483 beim Deutschen Patentamt (2001)

Kahmann S, Müller O: A new method for detecting DNA mutations
Anmeldung 01 07 317 beim Deutschen Patentamt (2001)

Böse G, Plaß M, Kuhlmann J, Müller O: An assay for the detection of primary DNA lesions based on the interaction of the DNA with DNA repair proteins
Patent PCT / EP 01 / 06591 (2001)

Müller O: The interaction of the APC wild-type tumor suppressor protein with DNA and its high nuclear level in proliferating cells as new tools in research and diagnostics – a new method for the detection of fast proliferating cells
Patent PCT / EP 00 / 06656 (2000)

Müller O, Sprenger-Haußels M, Bastian H, Vollert S: A method for purification of DNA from biological materials
Patent PCT / EP 98 / 00052 (2000)

Müller O, Deuter R: Process for purifying, stabilising or isolating nucleic acids from biological materials
Patent PCT / EP 96 / 03595 (1998)

Übersichtsartikel (Reviews), Buchkapitel, Bücher, Internetseiten, Kongressbeiträge


Müller, O. Altern. Sterben. Tod. : die Vergänglichkeit des Menschen aus der Sicht der Naturwissenschaften. Gütersloh: Gütersloher Verlagshaus (2019) ISBN: 9783579014715

"International Conference on Genetics & Molecular Reserach" in Dubai (2017) Doi: 10.29011/2574-7371-C1-003

Wagner C., Stocking C., Müller O. Cancer Signaling: From Molecular Biology to Targeted Therapy. Aufl. Weinheim: Wiley-Blackwell. (2016)

"13th Biotechnology Congress" in San Francisco (2016) Doi: 10.4172/2155-952X.C1.068

Apfel J., Parikh JR, Reischmann P., Ewing R.E., Müller O., Xia Y., Dominguez I. The Wnt signaling network in cancer. In S. Thiagalingam (Ed.), Systems Biology of Cancer (pp. 222-255). Cambridge: Cambridge University Press. (2015) doi: http://dx.doi.org/10.1017/cbo9780511979811.016

Wagener C, Stocking C, Müller O: Cancer Signaling: From Molecular Biology to Targeted Therapy
Lehrbuch, Wiley-VCH (2016) ISBN: 9783527336586

Apfel J, Parikh JR, Reischmann P, Ewing RM, Müller O, Xia Y, Dominguez, I: The Wnt pathway in Cancer.
Systems Biology of Cancer by Sam Thiagalingam (Editor) (2016). DOI: 10.4236/jbm.2016.412017

Wagener C, Müller O: www.youtube.com/Onkoview
Internet-Seite mit Animationen zur Molekularen Onkologie (2010)

Wagener C, Müller O: www.onkoview.com
Internet-Seite zum Lehrbuch „Molekulare Onkologie“ (2009)

Wagener C, Müller O: Molekulare Onkologie: Entstehung, Progression, klinische Aspekte
Lehrbuch, 3. Auflage, Georg Thieme Verlag Stuttgart (2009). ISBN: 978-3-13-103513-4

Vlad A, Röhrs S, Klein-Hitpass L, Müller O: The first five years of the Wnt targetome
Cellular Signalling, 20(5): 795-802 (2008). DOI: 10.1016/j.cellsig.2007.10.031

Hauss O, Müller O: The Protein Truncation Test (PTT) in mutation detection and molecular diagnosis
Methods in Molecular Biology: In vitro Transcription and Translation Protocols, Second Edition by Guido Grandi (Editor), Humana Press Totowa 375: 151-164 (2007). DOI: 10.1007/978-1-59745-388-2_8

Röhrs S, Müller O: The Wnt pathway as a target for novel anti-cancer drugs
Current Chemical Biology 1: 227-239 (2007)

Linke C, Müller O: Colorectal Cancer Screening: Molecular Diagnosis
Encyclopedia of Medical Genomics and Proteomics by Jürgen Fuchs & Maurizio Podda (Editors), Taylor & Francis Books New York 1(1): 1-5 (2007)

Müller O: Identification of colon cancer patients by molecular diagnosis
Digestive Diseases 21(4): 315-319 (2003). DOI: 10.1159/000075354

Chtarbova S, Müller O: Eine Frage zum Thema Krebs? Die Antwort weiß ganz allein der Wnt Signalweg
BioSpektrum 6: 701-703 (2003)

Müller O, Wittinghofer A: Ras binding compounds
Tumor Suppressing Viruses, Genes and Drugs – Innovative Cancer Therapy Approaches by Hiroshi Maruta (Editor), Academic Press New York, Chapter 15, 311-327 (2002)

Müller O: Die Analyse von DNA aus fäkalen Proben als Grundlage einer nicht invasiven molekularen Diagnose gastrointestinaler Tumoren
Fortschritt und Fortbildung in der Medizin, Band 25, S. 151-157, Bundesärztekammer, Köln (Hrsg.) Deutscher Ärzte-Verlag (2001)

Müller O: Methoden zur Isolierung und zur Analyse von DNA aus fäkalen Proben als Grundlage einer nicht-invasiven molekulargenetischen Tumor- und Infektionsdiagnostik.
Jahrbuch des Wissenschaftszentrums Nordrhein-Westfalen: 127-139 (1999)

Böse G, Deka J, Herter P, Müller O, Nimmrich I: Die Krebsentstehung auf molekularer Ebene
Jahrbuch der Max-Planck-Gesellschaft: 286-290 (1997)