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Veröffentlichungen

  • Habicher, Tobias and Czotscher, Vroni and Klein, Tobias and Daub, Andreas and Keil, Timm and Büchs, Jochen:Glucose-containing polymer rings enable fed-batch operation in microtiter plates with parallel online measurement of scattered light, fluorescence, dissolved oxygen tension and pH, In: Biotechnology and Bioengineering, 2019
  • Mundhada, Hemanshu and Seoane, Jose M and Schneider, Konstantin and Koza, Anna and Christensen, Hanne B and Klein, Tobias and Phaneuf, Patrick V and Herrgard, Markus and Feist, Adam M and Nielsen, Alex T:Increased production of L-serine in Escherichia coli through Adaptive Laboratory Evolution, In: Metabolic Engineering, Vol. 39, S. 141--150, 2017
  • Klein, Tobias and Niklas, Jens and Heinzle, Elmar:Engineering the supply chain for protein production/secretion in yeasts and mammalian cells, In: Journal of industrial microbiology \& biotechnology, Vol. 42, S. 453--464, 2015
  • Klein, Tobias and Lange, Sabrina and Wilhelm, Nadine and Bureik, Matthias and Yang, Tae-Hoon and Heinzle, Elmar and Schneider, Konstantin:Overcoming the metabolic burden of protein secretion in Schizosaccharomyces pombe--A quantitative approach using 13 C-based metabolic flux analysis, In: Metabolic engineering, Vol. 21, S. 34--45, 2014
  • Urbanova, Veronika and Kohring, Gert-Wieland and Klein, Tobias and Wang, Zhijie and Mert, Olcay and Emrullahoglu, Mustafa and Buran, Kerem and Demir, Ayhan S and Etienne, Mathieu and Walcarius, Alain:Sol-gel Approaches for Elaboration of Polyol Dehydrogenase-Based Bioelectrodes, In: Zeitschrift für Physikalische Chemie, Vol. 227, S. 667--689, 2013
  • Lis, Alicia V and Schneider, Konstantin and Weber, Jost and Keasling, Jay D and Jensen, Michael Krogh and Klein, Tobias:Exploring small-scale chemostats to scale up microbial processes: 3-hydroxypropionic acid production in S. cerevisiae, In: Microbial cell factories, Vol. 18, S. 50, 2019
  • Neutsch, Lukas and Kroll, Paul and Brunner, Matthias and Pansy, Alexander and Kovar, Michael and Herwig, Christoph and Klein, Tobias:Media photo-degradation in pharmaceutical biotechnology--impact of ambient light on media quality, cell physiology, and IgG production in CHO cultures, In: Journal of Chemical Technology \& Biotechnology, Vol. 93, S. 2141--2151, 2018
  • Hung, Chien-Wen and Klein, Tobias and Cassidy, Liam and Linke, Dennis and Lange, Sabrina and Anders, Uwe and Bureik, Matthias and Heinzle, Elmar and Schneider, Konstantin and Tholey, Andreas:Comparative proteome analysis in schizosaccharomyces pombe identifies metabolic targets to improve protein production and secretion, In: Molecular \& Cellular Proteomics, S. mcp--M115, 2016
  • Zalai, Denes and Koczka, Krisztina and P\'arta, L\'aszl\'o and Wechselberger, Patrick and Klein, Tobias and Herwig, Christoph:Combining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process, In: Biotechnology progress, Vol. 31, S. 1657--1668, 2015
  • Klein, Tobias and Heinzle, Elmar and Schneider, Konstantin:Metabolic fluxes in Schizosaccharomyces pombe grown on glucose and mixtures of glycerol and acetate, In: Applied microbiology and biotechnology, Vol. 97, S. 5013--5026, 2013
  • Habicher, Tobias and Klein, Tobias and Becker, Jacqueline and Daub, Andreas and Büchs, Jochen:Screening for optimal protease producing Bacillus licheniformis strains with polymer-based controlled-release fed-batch microtiter plates, In: Microbial Cell Factories, Vol. 20, S. 1--12, 2021
  • Habicher, Tobias and John, Arian and Scholl, Niklas and Daub, Andreas and Klein, Tobias and Philip, Priya and Büchs, Jochen:Introducing substrate limitations to overcome catabolite repression in a protease producing Bacillus licheniformis strain using membrane-based fed-batch shake flasks, In: Biotechnology and Bioengineering, 2019
  • Habicher, Tobias and Rauls, Edward KA and Egidi, Franziska and Keil, Timm and Klein, Tobias and Daub, Andreas and Büchs, Jochen:Establishing a Fed-Batch Process for Protease Expression with Bacillus licheniformis in Polymer-Based Controlled-Release Microtiter Plates, In: Biotechnology journal, 2019
  • Brunner, Matthias and Doppler, Philipp and Klein, Tobias and Herwig, Christoph and Fricke, Jens:Elevated pCO2 affects the lactate metabolic shift in CHO cell culture processes, In: Engineering in Life Sciences, Vol. 18, S. 204--214, 2018
  • Kildegaard, Kanchana R and Jensen, Niels B and Schneider, Konstantin and Czarnotta, Eik and Özdemir, Emre and Klein, Tobias and Maury, J\'er\^ome and Ebert, Birgitta E and Christensen, Hanne B and Chen, Yun and others:Engineering and systems-level analysis of Saccharomyces cerevisiae for production of 3-hydroxypropionic acid via malonyl-CoA reductase-dependent pathway, In: Microbial cell factories, Vol. 15, S. 53, 2016
  • Zhang, Lin and Vilà, Neus and Klein, Tobias and Kohring, Gert-Wieland and Mazurenko, Ievgen and Walcarius, Alain and Etienne, Mathieu:Immobilization of Cysteine-Tagged Proteins on Electrode Surfaces by Thiol--Ene Click Chemistry, In: ACS applied materials \& interfaces, Vol. 8, S. 17591--17598, 2016
  • Klein, Tobias and Heinzle, Elmar and Schneider, Konstantin:Acetate-containing substrate mixtures improve recombinant protein secretion in Schizosaccharomyces pombe, In: Engineering in Life Sciences, Vol. 15, S. 437--442, 2015
  • Klein, Tobias and Heinzel, Nicole and Kroll, Paul and Brunner, Matthias and Herwig, Christoph and Neutsch, Lukas:Quantification of cell lysis during CHO bioprocesses: Impact on cell count, growth kinetics and productivity, In: J Biotechnol, 2015
  • Kroll, Paul and Sagmeister, Patrick and Reichelt, Wieland and Neutsch, Lukas and Klein, Tobias and Herwig, Christoph:Ex situ online monitoring: application, challenges and opportunities for biopharmaceuticals processes, In: Pharmaceutical Bioprocessing, Vol. 2, S. 285--300, 2014
  • Klein, Tobias and Schneider, Konstantin and Heinzle, Elmar:A system of miniaturized stirred bioreactors for parallel continuous cultivation of yeast with online measurement of dissolved oxygen and off-gas, In: Biotechnology and bioengineering, Vol. 110, S. 535--542, 2013

Prof. Dr. Tobias Klein

Fachbereiche

Angewandte Logistik- und Polymerwissenschaften

Sprechstunde

Nach Absprache

Campus

Pirmasens

Raum

B106