Arbeitsgruppe Enterisches Nervensystem

Veröffentlichungen

2016

Unger MM, Spiegel J, Dillmann KU, Grundmann D, Philippeit H, Bürmann J, Faßbender K, Schwiertz A, Schäfer KH. Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls. Parkinsonism Relat Disord. 2016 Aug 26. pii: S1353-8020(16)30323-6. doi: 10.1016/j.parkreldis.2016.08.019. [Epub ahead of print]
PMID: 27591074

Geisel N, Clasohm J, Shi X, Lamboni L, Yang J, Mattern K, Yang G, Schäfer KH, Saumer M. Microstructured Multilevel Bacterial Cellulose Allows the Guided Growth of Neural Stem Cells. Small. 2016 Aug 24. doi: 10.1002/smll.201601679. [Epub ahead of print]
PMID: 27555582

Grundmann D, Markwart F, Scheller A, Kirchhoff F, Schäfer KH. Phenotype and distribution pattern of nestin-GFP-expressing cells in murine myenteric plexus. Cell Tissue Res. 2016 Aug 13. [Epub ahead of print]
PMID: 27519533

Pfeifle VA, Gros SJ, Frongia G, Schäfer KH, Holland-Cunz S. Regenerative Capacity of the Enteric Nervous System after Ileoileal Anastomoses in a Rat Model. Eur J Pediatr Surg. 2016 Jul 27. [Epub ahead of print]
PMID: 27464355

Griffin S, Tittikpina NK, Al-Marby A, Alkhayer R, Denezhkin P, Witek K, Gbogbo KA, Batawila K, Duval RE, Nasim MJ, Awadh-Ali NA, Kirsch G, Chaimbault P, Schäfer KH, Keck CM, Handzlik J, Jacob C. Turning Waste into Value: Nanosized Natural Plant Materials of Solanum incanum L. and Pterocarpus erinaceus Poir with Promising Antimicrobial Activities. Pharmaceutics. 2016 Apr 19;8(2). pii: E11. doi: 10.3390/pharmaceutics8020011.
PMID: 27104554

Batawila K, Duval RE, Nasim MJ, Awadh-Ali NA, Kirsch G, Chaimbault P, Schäfer KH, Keck CM, Handzlik J, Jacob C. Turning Waste into Value: Nanosized Natural Plant Materials of Solanum incanum L. and Pterocarpus erinaceus Poir with Promising Antimicrobial Activities.
Pharmaceutics. 2016 Apr 19;8(2). pii: E11. doi: 10.3390/pharmaceutics8020011.
PMID: 27104554

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schäfer KH, Metzger M, Hotta R, Young HM, Andrews PW, Thapar N, Belkind-Gerson J, Bondurand N, Bornstein JC, Chan WY, Cheah K, Gershon MD, Heuckeroth RO, Hofstra RM, Just L, Kapur RP, King SK, McCann CJ, Nagy N, Ngan E, Obermayr F, Pachnis V, Pasricha PJ, Sham MH, Tam P, Berghe PV. Dev Biol. 2016 Apr 5. pii: S0012-1606(16)30111-7. doi:
10.1016/j.ydbio.2016.04.001.

Heuckeroth RO, Schäfer KH. Gene-environment interactions and the enteric nervous system: Neural plasticity and Hirschsprung disease prevention.
Dev Biol. 2016 Mar 17. pii: S0012-1606(16)30003-3. doi:
10.1016/j.ydbio.2016.03.017.

Estevam EC, Griffin S, Nasim MJ, Denezhkin P, Schneider R, Lilischkis R, Dominguez-Alvarez E, Witek K, Latacz G, Keck C, Schäfer KH, Kieć-Kononowicz K, Handzlik J, Jacob C. Natural selenium particles from Staphylococcus carnosus: Hazards or particles with particular promise?
J Hazard Mater. 2016 Feb 2. pii: S0304-3894(16)30083-8. doi:
10.1016/j.jhazmat.2016.02.001.

Di Liddo R, Bertalot T, Schuster A, Schrenk S, Müller O, Apfel J, Reischmann P, Rajendran S, Sfriso R, Gasparella M, Parnigotto PP, Conconi MT, Schäfer KH. Fluorescence-based gene reporter plasmid to track canonical Wnt signaling in ENS inflammation. Am J Physiol Gastrointest Liver Physiol. 2016 Mar 15;310(6):G337-46. doi:
10.1152/ajpgi.00191.2015.

Subramanya SB, Stephen B, Nair SS, Schäfer KH, Lammers WJ.Effect of Ethanol Exposure on Slow Wave Activity and Smooth Muscle Contraction in the Rat Small Intestine. Dig Dis Sci. 2015 Dec;60(12):3579-89. doi:
10.1007/s10620-015-3813-7.

2015

Di Liddo R, Bertalot T, Schuster A, Schrenk S, Tasso A, Zanusso I,Conconi M, Schäfer KH. Anti-inflammatory activity of Wnt signaling in enteric nervous system: in vitro preliminary evidences in rat primary cultures. J Neuroinflammation. 2015 Feb 3;12(1):23. doi: 10.1186/s12974-015-0248-1.

Isolation of high-purity myenteric plexus from adult human and mouse gastrointestinal tract. Grundmann D, Klotz M, Rabe H, Glanemann M, Schäfer KH.Sci Rep. 2015 Mar 20;5:9226. doi: 10.1038/srep09226.

Degradation of intestinal mRNA: A matter of treatment. Heumüller-Klug S, Sticht C, Kaiser K, Wink E, Hagl C, Wessel L, Schäfer KH.World J Gastroenterol. 2015 Mar 28;21(12):3499-508. doi: 10.3748/wjg.v21.i12.3499


2014

Schuster A, Klotz M, Schwab T, Di Liddo R, Bertalot T, Schrenk S, Martin M, Nguyen TD, Nguyen TNQ, Gries M, Faßbender K, Conconi MT, Parnigotto PP, Schäfer KH. Maintenance of the enteric neural stem cell niche by bacterial Lipopolysaccarides, Journal of Cellular and Molecular Medicine, 2014, doi: 10.1111/jcmm.12292. IF: 4,8

Schreiber D, Klotz M, Laures K, Clasohm J, Bischof M, Schäfer KH.The mesenterially perfused rat small intestine: A versatile approach for pharmacological testings. Ann Anat. 2014 May;196(2-3):158-66., IF: 1,9

Kadas G,  Klotz M, Schäfer KH, Fassbender K, Thomi D, Oertel WH, Unger M. Do different assays for human acylated ghrelin concentrations provide comparable results?Neuro Endocrinol Lett, 2014;35(1):37-41. IF: 1,1

Schreiber D, Jost V, Bischof M, Seebach K, Lammers WJ, Douglas R, Schäfer KH. Motility patterns of ex vivo intestine segments depend on perfusion mode. World J Gastroenterol. 2014 Dec 28;20(48):18216-27. doi: 10.3748/wjg.v20.i48.18216.

Schrenk S, Schuster A, Klotz M, Schleser F, Lake J, Heuckeroth RO, Kim YJ, Laschke MW, Menger MD, Schäfer KH. Vascular and neural stem cells in the gut: do they need each other? Histochem Cell Biol. 2014 Nov 5. [Epub ahead of print]

Koppenhöfer D, Kettenbaum F, Susloparova A, Law JK, Vu XT, Schwab T, Schäfer KH, Ingebrandt S. Neurodegeneration through oxidative stress: Monitoring hydrogen peroxide induced apoptosis in primary cells from the subventricular zone of BALB/c mice using field-effect transistors. Biosens Bioelectron. 2015 May 15;67:490-6. doi: 10.1016/j.bios.2014.09.012. Epub 2014 Sep 8.

Ma MS, Czepiel M, Krause T, Schäfer KH, Boddeke E, Copray S.Generation of induced pluripotent stem cells from hair follicle bulge neural crest stem cells. Cell Reprogram. 2014 Oct;16(5):307-13.
Gress C, Jeziroski M., Saumer M., Schäfer KH. Simulation of in-vivo-equivalent epithelial barriers using a micro fluidic device. 2014, Biomedical Microdevices, . Apr;16(2):191-8.,

Demir IE, Tieftrunk E, Schäfer KH, Friess H, Ceyhan GO. Simulating pancreatic neuroplasticity: in vitro dual-neuron plasticity assay. JoVE, 2014 Apr 14;(86). doi: 10.3791/51049

Schuster A, Klotz M,Schwab T,Lilischkis R, Armin Schneider A, Schäfer KH. Granulocyte-colony stimulating factor: a new player for the Enteric Nervous System. 2014, Cell and Tissue Research, 355(1):35-48


2013

Hagl CI, Heumüller-Klug S, Wink E, Wessel LM, Schäfer KH. From the Appendix to the Brain: The human gastrointestinal tract, a potential autologous neural stem cell source. PLoS One. 2013, e72948. doi:10.1371/journal.pone.0072948.


Böttner M, Barrenschee M, Hellwig I, Harde J, Egberts JH, Becker T, Zorenkov D, Schäfer KH, Wedel T. The GDNF System Is Altered in Diverticular Disease - Implications for Pathogenesis. PLoS One. 2013 Jun 21;8(6):e66290.

Lee J, Miró MM, Akkan CK, Haidar A, Metzger W, Schwarz LK, Zaporojtchenko V, Schäfer KH, Abdul-Khaliq H, Veith M, Aktas C. Development of multi scale structured Al/AI2O3 nanowires for controlled cell guidance. J Biomed Nanotechnol. 2013 Feb;9(2):295-8.

Semar S, Klotz M, Letiembre M, Van Ginneken C, Braun A, Jost V, Bischof M, Lammers WJ, Liu Y, Fassbender K, Wyss-Coray T, Kirchhoff F, Schäfer KH. Changes of the enteric nervous system in Amyloid Precursor Protein transgenic mice correlate with disease progression. Journal of Alzheimers Disease, 2013, 36(1):7-20. doi: 10.3233/JAD-120511.

Hagl CI, Schäfer KH, Hellwig I, Barrenschee M, Harde J, Holtmann M, Porschek S, Egberts JH, Becker T, Wedel T, Böttner M. Expression and function of the Transforming Growth Factor-ß system in the human and rat enteric nervous system. Neurogastroenterology and Motility, 2013 Jul;25(7):601-e464

Demir IE, Schäfer KH, Tieftrunk E, Friess H, Ceyhan GO. Neural plasticity in the gastrointestinal tract: chronic inflammation, neurotrophic signals and hypersensitivity. Acta Neuropathol. 2013. 125(4):491-509.

Medert R, Schuster A, Schwarz LK, Schwab T, Schäfer KH. Spiking rate of myenteric neurons recorded from multi-electrode arrays depends on local microenvironment. Physica status solidi 2013. Volume 10, 877–881,

Lee J, Schwarz LK, Akkan CK, Miro MM, Schäfer KH, Veith M, Aktas C. Laser induced periodic patterns on biphasic core/shell nanowires for neurite guidance. Physica status solidi , 2013. Volume 210, Pages: 952–956

Wu B, Braun A, Ediger S, Huang W, Lilischkis R, Schäfer KH, Wu Q, Zhang X, Saumer S, Investigations on surface quality and biocompatibility of porous hydroxyapatite scaffolds for bone tissue engineering, Physica status solidii  2013. Volume 210,  Pages: 957–963

Kaltwaßer B, Schulenborg T, Beck F, Klotz M, Schäfer KH, Schmitt M, Sickmann A, Friauf E. Developmental changes of the protein repertoire in the rat auditory brainstem: a comparative proteomics approach in the superior olivary complex and the inferior colliculus with DIGE and iTRAQ.J Proteomics. 2013 Feb 21;79:43-59.

Hagl CI, Wink E, Scherf S, Heumüller S, Hausott B Schäfer KH. FGF2 deficit during development leads to specific neuronal cell loss in the enteric nervous system. Histochem Cell Biol, 2013, 139(1):47-57.
Schuster A, Schwab T, Bischof M, Klotz M, Lemor R, Degel C, Schäfer KH. Cell specific ultrasound effects are dose and frequency dependent. Annals of Anatomy, 2013, 195(1):57-67.


2012

Hagl CI, Wink E, Weiss C, Wessel L, Gretz N, Schäfer KH. Enteric neurons from postnatal Fgf2 knockout mice differ in neurite outgrowth responses. Auton Neurosci. 2012, 170(1-2):56-61

Hagl CI, Rauch U, Klotz M, Heumüller S, Grundmann D, Ehnert S, Subotic U, Holland-Cunz S, Schäfer KH. The microenvironment in the Hirschsprung's disease gut supports myenteric plexus growth. Int J Colorectal Dis. 2012,  27(6):817-29

Ali AA, Nimir H, Aktas C, Huch V, Rauch U, Schäfer KH, Veith M. Organoplatinum(II) Complexes with 2-Acetylthiophene Thiosemicarbazone: Synthesis, Characterization, Crystal Structures, and in Vitro Antitumor Activity. Organometallics, 2012, 31 (6), pp 2256–2262

Hagl CI, Heumüller S, Klotz M, Subotic U, Wessel L, Schäfer KH. Smooth muscle proteins from Hirschsprung's disease facilitates stem cell differentiation. Pediatr Surg Int. 2012 Feb;28(2):135-42.


2011

Fichter M, Klotz M, Hirschberg DL, Waldura B, Schofer O, Ehnert S, Schwarz LK, Ginneken CV, Schäfer KH. Breast milk contains relevant neurotrophic factors and cytokines for enteric nervous system development. Mol Nutr Food Res. 2011 Oct;55(10):1592-6. 3

Preuss KD, Pfreundschuh M, Fadle N, Regitz E, Raudies S, Murwaski N, Ahlgrimm M, Bittenbring J, Klotz M, Schäfer KH, Held G, Neumann F, Grass S. Hyperphosphorylation of autoantigenic targets of paraproteins is due to inactivation of PP2A. Blood. 2011 Sep 22;118(12):3340-6.

Van Ginneken CJ, Schäfer KH, Van Dam D, Huygelen V; De Deyn PP,  Morphological changes in the enteric nervous system of aging and APP23 transgenic mice.  Brain Research, 2011, 1378, 43-53 IF: 2,879


2010

Ceyhan GO, Schäfer KH, Kerscher AG, Rauch U, Demir IE, Kadihasanoglu M, Böhm C, Müller MW, Büchler MW, Giese NA, Erkan M, Friess H.Nerve growth factor and Artemin are paracrine mediators of pancreatic neuropathy in pancreatic adenocarcinoma. Ann Surg. 2010. 251:923-31

Demir IE, Ceyhan GO, Rauch U, Altintas B, Klotz M, Müller MW, Büchler MW, Friess H, Schäfer KH. The microenvironment in chronic pancreatitis and pancreatic cancer induces neuronal plasticity. Neurogastroenterol Motil. 2010, 22:480-90


2009

Mustaffa I, Trenado C, Rahim HR, Schafer KH, Strauss DJ. Sharpening of neurite morphology using complex coherence enhanced diffusion. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:3593-6.
Schäfer KH, Van Ginneken C, Copray S. Plasticity and neural stem cells in the enteric nervous system. Anat Rec (Hoboken). 2009 Dec;292(12):1940-52.

Ceyhan GO, Demir IE, Rauch U,  Bergmann F, Müller MW, Büchler MW, Friess H, Schäfer KH. Pancreatic neuropathy results in “neural remodelling” and altered pancreatic innervation in chronic pancreatitis and pancreatic cancer . American Journal of Gastroenterology, 2009. 104, :2555-65.

Schneider P., Steitz C., Schäfer KH and Ziegler C. Hot embossing of pyramidal microstructures in PMMA for cell culture, Physica status solidi(a), 2009. Volume 206, Pages: 501–507

Kohr D, Tschernatsch M, Schmitz K, Singh P, Kaps M, Schäfer KH, Diener M, Mathies J, Matz O, Kummer W, Maihöfner C, Fritz T, Birklein F, Blaes F. Autoantibodies in complex regional pain syndrome bind to a differentiation-dependent neuronal surface autoantigen. Pain. 2009. Volume 143, 246-251

Schäfer KH, Micci MA, Pasricha PJ. Neural stem cell transplantation in the enteric nervous system: roadmaps and roadblocks. Neurogastroenterol Motil. 2009 Feb;21(2):103-12.


2008

Ceyhan GO, Demir IE, Altintas B, Rauch U, Thiel G, Müller MW, Giese NA, Friess H, Schäfer KH. Neural invasion in pancreatic cancer: a mutual tropism between neurons and cancer cells. Biochem Biophys Res Commun. 2008 Sep 26;374(3):442-7.

Tschernatsch M, Klotz M, Probst C, Hosch J, Valtorta F, Diener M, Gerriets T, Kaps M, Schäfer KH, Blaes F , Synaptophysin is an autoantigen in paraneoplastic neuropathy, J Neuroimmunol. 2008 Jul;197: 81-6.

Hagl CI, Klotz M, Wink E, Kränzle K, Holland-Cunz S, Gretz N, Diener M, Schäfer KH. Temporal and regional morphological differences as a consequence of FGF-2 deficiency are mirrored in the myenteric proteome   Ped. Surg. Int  2008, 24: 49-60


2007

S. Holland-Cunz, M. Chmelnik, M. Roll, K.L. Waag, K.H. Schäfer. The clipped intestinal non perforating anastomosis (CINPA) of small bowel – a new technique Pediatr Surg Int. 2007, 23: 87-93.


2006

von Boyen GB, Steinkamp M, Reinshagen M, Schäfer KH, Adler G, Kirsch J. Nerve Growth Factor Secretion in Cultured Enteric Glia Cells is modulated by Proinflammatory Cytokines. J Neuroendocrinol. 2006, 18(11):820-825.

von Boyen GB, Steinkamp M, Geerling I, Reinshagen M, Schäfer KH, Adler G, Kirsch J. Proinflammatory Cytokines Induce Neurotrophic Factor Expression in Enteric Glia: A Key to the Regulation of Epithelial Apoptosis in Crohn's Disease.Inflammatory Bowel Disease . 2006, 24: 346-354.

Holland-Cunz S, Schäfer KH, Günther G und Waag KL,Die angeborene segmentale Dilatation des Dünndarms, chirurgische Praxis, 2006, 65, 641-646

Holland-Cunz S, Goppl M, Rauch U, Bar C, Klotz M, Schäfer KH. Acquired intestinal aganglionosis after a lytic infection with varicella-zoster virus. J Pediatr Surg. 2006 Mar;41(3):29-31.

Bruley des Varannes S, Chevalier J, Pimont S, Le Neel JC, Klotz M, Schafer KH, Galmiche JP, Neunlist M. The serum of achalasia patients alters neurochemical coding in the myenteric plexus and NO-mediated motor response in normal human fundus. GUT,  2006 Mar;55(3):319-26

Rauch U, Hansgen A, Hagl C, Holland-Cunz S, Schäfer KH. Isolation and cultivation of neuronal precursor cells from the developing human enteric nervous system as a tool for cell therapy in dysganglionosis.. nternational Journal of Colorectal Diseases. 2006, 21: 554-559.


2005

Hagl CI, Thil O, Holland-Cunz S, Faissner R, Wandschneider S, Schnölzer M, Löhr M, Schäfer KH. Proteome analysis of isolated myenteric plexus reveals significant changes in protein expression during postnatal development. Auton Neurosci. 2005, 122:1-8.

Rauch U, Klotz M, Maas-Omlor S, Wink E, Hansgen A, Hagl C, Holland-Cunz S, Schäfer KH. Expression of Intermediate Filament Proteins and Neuronal Markers in the Human Fetal Gut. J Histochem Cytochem. 2005, 54: 39-46


2004

Beiler HA, Schäfer KH, Hagl C, Steinorth C, Witt A, Zachariou Z. Histological changes in neuronal innervation of the ileummucosa after autologic-allotopic ileummucosa transplantation. Ped Surg Int. 2004. 20(2):96-100I

Holland-Cunz , S. Bainczyk , C.Hagl ,E. Wink, T.Wedel , W. Back , K-H Schäfer.  Three dimensional co-culture model of enterocytes and primary enteric neuronal tissue. Ped Surg Int.2004
von Boyen GBT, Steinkamp M, Reinshagen M, Schäfer KH, Adler G, Kirsch J. Proinflammatory cytokines increase GFAP expression in enteric glia  GUT, 2004, 53(2): 222-8,


2003

Schultheiss G,  Ribeiro R, Schäfer KH, Diener M. Activation of apical K+-conductances by muscarinic receptor stimulation in rat distal colon: fast and slow components. Journal of Membrane Biology, . 2003. 195(3): 183-96.

Hagl CI,  Holland-Cunz S, Schäfer KH. What does knock-out-models teach us about the enteric Nervous system? European Journal of Paediatric Surgery, 2003. 13, 170-175,

Schäfer KH, Hagl CI, Wink E, Holland-Cunz S, Klotz M, Rauch U, Waag KLHow to approach the ENS: Various ways to analyze motility disorders in situ and in vitro. European Journal of Paediatric Surgery, 2003. 13, 163-169,

Hagl CI, Wink E, Kränzle K, Hänsgen A, Diener M, Gretz N, Schäfer KH. Are animals a suitable model for motility disorders? Current views upon ENS development and own experiences with a FGF-knock-out model. Biomedical Research, 2003.14(1), 87-91

Rauch U, Schäfer KH. The extracellular matrix and its role in cell migration and development of the enteric nervous system. European Journal of Pediatric Surgery, 2003. 13, 158-162,

Holland-Cunz S, Hagl CI, Krammer HJ, Lintz M,  Wessel L, Schäfer KH. Three-dimensional cultures of dissociated myetenric plexus as a model for the development of the enteric nervous system. Biomedical Research, 2003. 14(1), 92-99

Schäfer KH, Hagl CI, Rauch R. Differentiation of  neurospheres from the enteric nervous system. Pediatric Surgery International, 2003,.19, 340-344,


2002

Brizzolara  A, Favre A, Schäfer KH, Michelazzi A, Sanguineti M, Martucciello G,  Jasonni V. Mouse isolated plexus differentiates neural crest precursors into enteric neuroblasts, European Journal of Paediatric Surgery,  2002. 12(6):391-6,

Hosie S, Farag F, Vena M, Holloschi A, Schäfer KH. The role of contractile microfilaments in the morphogenesis of the developing foregut of chick embryos Pediatric Surgery International, 2002. 18: 611-614,

Dudek J, Volkmer J, Bies, C Guth S, Müller A, Lerner M, Feick P, Schäfer KH, Morgenstern E, Hennessy F, Blatch GL, Janoscheck K, Heim N, Scholtes P, Frien M, Nastainczyk W, Zimmermann R. A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes. EMBO Journal  2002. 21: 2958-2967,