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Method of treating or preventing central nervous system disorders using 1-ar(alk)ylimidazolin-2-ones; AKZ: 29900P, US 60/486678.

In Anmeldung beim Deutschen Patent- und Markenamt: „Kulturfreie Nutzung von Microelectrode-Arrays zur Ableitung erregbarer Zellen in vitro: Upside-Down MEA in Single and Co-culture Modus.“ Erfinder: Prof. K-H Schäfer, Dr. rer. nat. Holger Rabe und Dipl. Ing. Sebastian Schlüter.


Rabe, Holger (1999): Untersuchungen zur Physiologie von Neuronen und radialen Gliazellen im Sehzentrum der Regenbogenforelle (Oncorhynchus mykiss).

Autorenschaft der letzten 10 Jahre in „peer reviewed“ Zeitschriften:

Saarelainen, K. S., Ranna, M., Rabe, H., Sinkkonen, S. T., Möykkynen, T., Uusi-Oukari, M., Linden, A.-M., Lüddens, H., Korpi, E. R. (2008). Enhanced behavioral sensitivity to the competitive GABA agonist, gaboxadol, in transgenic mice over-expressing hippocampal extrasynaptic  GABAA receptors. Journal of Neurochemistry 105:338-350.

Jansen, M., Rabe, H., Strehle, A., Dieler, S., Debus, F., Dannhardt, G., Akabas, M. A., Lüddens, H. (2008). Synthesis of GABAA Receptor Agonists and Evaluation of their -Subunit Selectivity and Orientation in the GABA Binding Site. J. Med. Chem. 51:4430–4448.

Leppä, E., Linden, A. M., Rabe, H., Vekovischeva, O. Y., Wulff, P., Lüddens, H., Wisden, W., Korpi, E. R. (2011). Actions of two GABAA receptor benzodiazepine-site ligands that are mediated via non-2-dependent modulation. Europ. J. Pharmacol., 666 (1–3): 111–121.

Ludwig, J., Rabe, H., Höffle-Maas, A., Samochocki, M., Maelicke, A., Kaletta, T. (2013). Directed Mutagenesis of Nicotinic Receptors to Investigate Receptor Function. In: Genetic Manipulation of DNA and Protein - Examples from Current Research. (Edited by David Figurski), Publisher InTech, ISBN 978-953-51-0994-5.

Schreiber, D., Erkel, G., Schäfer, M., Marx, L., Klotz, M., Rabe, H., Martin, M., and, Schäfer, K-H (2014). Checking novel antiinflammatory drugs on neuroinflammatory processes in the isolated enteric nervous system (2014). Neurogastroenterology and Motility 26:38

Grundmann, D., Klotz, M., Rabe, H., Glanemann, M., Schäfer, K-H. (2015). Isolation of high-purity myenteric plexus from adult human and mouse gastrointestinal tract. Scientific Reports 5:9226

Rabe, H., Schwarz, L., Grundmann, D., Schäfer, K-H. (2016). Multi-electrode-array (MEA) recordings from myenteric plexus in vitro dependent on the culture mode. Neurogastroenterology and Motility 28:53.

Gondré-Lewis, M.C., Warnock, K.T., Wang, H., June, H.L.Jr., Bell, K.B., Rabe, H., Tiruveedhula, V., Cook, J., Lüddens, H., Aurelian, L., and June, H.L.Sr (2016). Early life stress is a risk factor for excessive alcohol drinking and impulsivity in adults and is mediated via a CRF/GABAA mechanism. Stress 19(2):1-13

Grundmann, D., Klotz, M., Burkhard, W., Schreiber, D., Simon, D., Rabe, H., Abdel-Aziz, H., Kel-ber, O. and Schäfer, K-H (2016). Tu1443 Influences of STW 5, a Multi-Component Herbal Preparation, on Motility and Inflammation Challenges in Gut and Enteric Nervous System (ENS). Gastroenterology 150(4):S905

Wesentlichste Kongressbeiträge der letzten 5 Jahre:

11th International Meeting on Substrate-Integrated Microelectrode Arrays; July 2018
Decker, D., Pirrung, M., Gries, M., Ingebrandt, S., Schäfer, K-H., Saumer, M., Rabe, H.. Impedance of 3D Nanostructured MEAs: Influence of Coating and Cell Cultivation

Biosensors 2014
Rabe, H., Braun, A., Grimm, M., Hartmann, T., Schäfer, KH.. Using MEA technology for pharmacological screenings in Alzheimer’s disease.
Schwartz, L., Rabe, H., Grundmann, D., Schäfer, KH.. MEA recordings from myenteric plexus in vitro depend on the culture mode.

European Neurogastroenterology meetings – NeuroGASTRO 2017
Clasohm, J., Ull-Sopha1, S., Stoye, N., Endres, K., Rabe, H., Schäfer, K-H.. Functional compensation of gastro intestinal motility indicates enteric plasticity in an early onset model of Alzheimer’s Disease.

International Conference in Advanced Manufacturing for Multifunctional Miniaturised Devices (M6)
2013: H. Rabe, A. Braun, K-H. Schäfer. Does the biological nanoparticle, the amyloid ß peptide, influence directly the enteric nervous system?
2015: D. Decker, H. Rabe, M. Saumer. Development of 3D-nanostructured electrodes for biosensing applications

Neuroscience meeting
2014: Rabe, H., Braun, A., Grimm, M., Hartmann, T., Schäfer, KH. Acute effects of amyloid beta 42 on the GUT enteric nervous System (ENS)